Reference - Detail
| RRC ID | 38905 |
|---|---|
| Author | Shi YH, Zhu S, Ge YW, He YM, Kazuma K, Wang Z, Yoshimatsu K, Komatsu K. |
| Title | Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora. |
| Journal | Fitoterapia |
| Abstract |
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed. |
| Volume | 108 |
| Pages | 55-61 |
| Published | 2016-1-1 |
| DOI | 10.1016/j.fitote.2015.11.011 |
| PII | S0367-326X(15)30120-9 |
| PMID | 26598138 |
| MeSH | Animals Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology* Cell Line, Tumor Molecular Structure Monoterpenes / isolation & purification Monoterpenes / pharmacology* Paeonia / chemistry* Plant Extracts / chemistry Plant Roots / chemistry* Rats |
| IF | 2.527 |
| Times Cited | 18 |
| WOS Category | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | RBL 2H3(RCB2782) |