| RRC ID |
38905
|
| Author |
Shi YH, Zhu S, Ge YW, He YM, Kazuma K, Wang Z, Yoshimatsu K, Komatsu K.
|
| Title |
Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
|
| Journal |
Fitoterapia
|
| Abstract |
The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
|
| Volume |
108
|
| Pages |
55-61
|
| Published |
2016-1-1
|
| DOI |
10.1016/j.fitote.2015.11.011
|
| PII |
S0367-326X(15)30120-9
|
| PMID |
26598138
|
| MeSH |
Animals
Anti-Allergic Agents / isolation & purification
Anti-Allergic Agents / pharmacology*
Cell Line, Tumor
Molecular Structure
Monoterpenes / isolation & purification
Monoterpenes / pharmacology*
Paeonia / chemistry*
Plant Extracts / chemistry
Plant Roots / chemistry*
Rats
|
| IF |
2.527
|
| Times Cited |
18
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
CHEMISTRY, MEDICINAL
|
| Resource |
| Human and Animal Cells |
RBL 2H3(RCB2782) |
