RRC ID 38905
著者 Shi YH, Zhu S, Ge YW, He YM, Kazuma K, Wang Z, Yoshimatsu K, Komatsu K.
タイトル Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.
ジャーナル Fitoterapia
Abstract The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
巻・号 108
ページ 55-61
公開日 2016-1-1
DOI 10.1016/j.fitote.2015.11.011
PII S0367-326X(15)30120-9
PMID 26598138
MeSH Animals Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology* Cell Line, Tumor Molecular Structure Monoterpenes / isolation & purification Monoterpenes / pharmacology* Paeonia / chemistry* Plant Extracts / chemistry Plant Roots / chemistry* Rats
IF 2.527
引用数 18
WOS 分野 PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
リソース情報
ヒト・動物細胞 RBL 2H3(RCB2782)