Reference - Detail
RRC ID | 38935 |
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Author | Nakajima M, Shinoda I, Samejima Y, Miyauchi H, Fukuwatari Y, Hayasawa H. |
Title | Kappa-casein suppresses melanogenesis in cultured pigment cells. |
Journal | Pigment Cell Res |
Abstract |
The effects of bovine milk proteins on melanogenesis in B16 cells were examined. Both whey protein isolate and casein exhibited depigmenting properties. Among the major protein components of milk--including beta-lactoglobulin, alpha-lactalbumin, alpha-, beta-, and kappa-casein--only kappa-casein exhibited the depigmenting effect. However, the carboxyl terminal peptide of kappa-casein, glycomacropeptide, did not show this activity. Also, kappa-casein promoted the proliferation of the cells and inhibited the activity of tyrosinase in the cells. These results indicate that kappa-casein acts as a melanogenesis-suppressing modulator. |
Volume | 9(5) |
Pages | 235-9 |
Published | 1996-10-1 |
DOI | 10.1111/j.1600-0749.1996.tb00112.x |
PMID | 9014209 |
MeSH | Animals Caseins / pharmacology* Cattle Cell Division Melanins / analysis Melanocytes / cytology Melanocytes / drug effects* Melanocytes / enzymology Melanoma Mice Milk Proteins / pharmacology Monophenol Monooxygenase / metabolism Pigmentation / drug effects* Tumor Cells, Cultured Whey Proteins |
Times Cited | 9 |
WOS Category | DERMATOLOGY CELL BIOLOGY |
Resource | |
Human and Animal Cells | B16 melanoma 4A5(RCB0557) |