RRC ID |
38939
|
著者 |
Suzuki T, Ohno N, Chiba N, Miura NN, Adachi Y, Yadomae T.
|
タイトル |
Immunopharmacological activity of the purified insoluble glucan, zymocel, in mice.
|
ジャーナル |
J Pharm Pharmacol
|
Abstract |
Although it has been established that soluble glucan in fungi is important to host defence against infection, the importance of insoluble glucans is not clear. We have examined the in-vivo immunopharmacological activity of the insoluble glucan, zymocel. Administration of zymocel increased peritoneal exudate cell number and spleen weight, and enhanced: phagocytic activity, hydrogen peroxide production, and nitric oxide production of peritoneal exudate cells; the extravascular release of Evans blue (which might reflect vascular permeability); lipopolysaccharide-triggered synthesis of tumour necrosis factor (TNF); and recovery of white blood cell number in cyclophosphamide-induced leukopenia. Zymocel also showed anti-tumour activity against sarcoma 180 in mice and also enhanced TNF synthesis and hydrogen peroxide production by macrophage-like cell line in-vitro, i.e. resulted in direct macrophage activation. These results show that zymocel shows varied immunopharmacological activity; it is suggested that the administration of insoluble glucan induces the inflammatory response, the subsequent activation of the immune systems via the cytokine network, and direct macrophage activation.
|
巻・号 |
48(12)
|
ページ |
1243-8
|
公開日 |
1996-12-1
|
DOI |
10.1111/j.2042-7158.1996.tb03930.x
|
PMID |
9004185
|
MeSH |
Animals
Capillary Permeability / drug effects
Glucans / pharmacology*
Hydrogen Peroxide / metabolism
Macrophages, Peritoneal / drug effects
Male
Mice
Mice, Inbred ICR
Nitric Oxide / biosynthesis
Organ Size / drug effects
Phagocytosis / drug effects
Spleen / drug effects
Tumor Necrosis Factor-alpha / biosynthesis
|
IF |
2.571
|
引用数 |
11
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |