論文 - 詳細
| RRC ID | 38969 |
|---|---|
| 著者 | Suzuki A. |
| タイトル | Amyloid beta-protein induces necrotic cell death mediated by ICE cascade in PC12 cells. |
| ジャーナル | Exp Cell Res |
| Abstract |
A major component of Alzheimer's disease plaque amyloid beta protein (betaAP) showed the cytolytic activity to rat pheochromocytoma PC 12 cells. Nuclear morphological study revealed that betaAP-induced cytolytic activity is due to necrotic cell death, rather than apoptotic cell death. To examine the molecular machinery of betaAP-induced necrotic cell death in detail, I investigated the direct involvement of caspase. When nerve growth factor-treated and -untreated PC12 cells were incubated with the synthesized tetrapeptide inhibitors of caspase, YVAD-CHO (Ac-Tyr-Val-Ala-Asp-CHO) or DEVD-CHO (Ac-Asp-Glu-Val-Asp-CHO), betaAP-induced necrotic cell death was prevented. In addition, the interleukin-1beta converting enzyme (ICE) subfamily activation preceded CPP32 subfamily activation during betaAP-induced necrotic cell death. On the basis of these findings, I suggest that betaAP induces necrotic cell death mediated by the ICE cascade and that the ICE cascade may possibly be involved in Alzheimer's disease. |
| 巻・号 | 234(2) |
| ページ | 507-11 |
| 公開日 | 1997-8-1 |
| DOI | 10.1006/excr.1997.3639 |
| PII | S0014-4827(97)93639-9 |
| PMID | 9260921 |
| MeSH | Amyloid beta-Peptides / pharmacology* Animals Caspase 1 Caspase 3 Caspases* Cell Nucleus / drug effects Cysteine Endopeptidases / metabolism* Cysteine Proteinase Inhibitors / pharmacology Enzyme Activation Necrosis* Nerve Growth Factors / pharmacology Oligopeptides / pharmacology PC12 Cells Rats |
| IF | 3.383 |
| 引用数 | 38 |
| WOS 分野 | ONCOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |