| RRC ID |
39013
|
| Author |
Kobori M, Shinmoto H, Tsushida T, Shinohara K.
|
| Title |
Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport.
|
| Journal |
Cancer Lett
|
| Abstract |
Phloretin, a naturally occurring dihydrochalcone, is known to inhibit tumor cell growth in vitro and in vivo. To clarify the anti-tumor effects of phloretin, its apoptosis-inducing effects in B16 melanoma 4A5 cells were examined. Phloretin induced the internucleosomal DNA fragmentation typical of apoptosis in B16 melanoma cells. The addition of extracellular glucose remarkably inhibited the phloretin-induced apoptosis in the cells. When apoptosis was strongly induced in the B16 cells by phloretin, protein kinase C activity was inhibited in the cells. Our results suggest that phloretin induced apoptosis in B16 melanoma 4A5 cells mainly through the inhibition of glucose transmembrane transport. Inhibition of protein kinase C activity by phloretin probably promotes the ratio of apoptotic cells in the cells.
|
| Volume |
119(2)
|
| Pages |
207-12
|
| Published |
1997-11-11
|
| DOI |
10.1016/s0304-3835(97)00271-1
|
| PII |
S0304-3835(97)00271-1
|
| PMID |
9570373
|
| MeSH |
Animals
Apoptosis / drug effects*
Cell Membrane / drug effects
Cell Membrane / metabolism
Dose-Response Relationship, Drug
Glucose / pharmacokinetics*
Glucose / pharmacology
Melanoma, Experimental / enzymology
Melanoma, Experimental / physiopathology*
Mice
Phloretin / pharmacology*
Protein Kinase C / antagonists & inhibitors
Protein Kinase C / metabolism
|
| IF |
7.36
|
| Times Cited |
67
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
B16 melanoma 4A5(RCB0557) |
