RRC ID 39033
Author Takahashi H, Nakagawa S.
Title Effects of estrogen on cell growth and fibroblast growth factor receptor induction in MtT/Se cells.
Journal Endocr Res
Abstract The effects of estradiol (E2) on cell growth and the expression of fibroblast growth factor receptor (FGFR) were investigated in a cultured rat anterior pituitary cell line (MtT/Se) established from an E2-induced mammotropic pituitary tumor. E2 stimulated cell growth 2-3 fold as compared to the control. Basic fibroblast growth factor (bFGF) stimulated cell growth in the presence of E2 (10(-9) M) but not in the absence of E2. Tamoxifen as an antiestrogen agent inhibited the proliferation of MtT/Se cells which had been treated with E2 or E2 and bFGF. Numbers of FGFR in E2-stimulated MtT/Se cells significantly exceeded those in cells not treated with E2. These observations indicate that E2 plays an important role in the regulation of FGFR induction in the anterior pituitary cells.
Volume 23(1-2)
Pages 95-104
Published 1997-2-1
DOI 10.1080/07435809709031845
PMID 9187541
MeSH Animals Cell Division / drug effects Drug Evaluation, Preclinical Estradiol / pharmacology* Fibroblast Growth Factor 2 / pharmacology Immunoblotting Pituitary Gland, Anterior / cytology Pituitary Gland, Anterior / drug effects* Pituitary Gland, Anterior / metabolism Rats Receptors, Fibroblast Growth Factor / biosynthesis* Tamoxifen / pharmacology Tumor Cells, Cultured
IF 1.553
Times Cited 8
Human and Animal Cells MtT/Se(RCB0529)