論文 - 詳細
| RRC ID | 39033 |
|---|---|
| 著者 | Takahashi H, Nakagawa S. |
| タイトル | Effects of estrogen on cell growth and fibroblast growth factor receptor induction in MtT/Se cells. |
| ジャーナル | Endocr Res |
| Abstract |
The effects of estradiol (E2) on cell growth and the expression of fibroblast growth factor receptor (FGFR) were investigated in a cultured rat anterior pituitary cell line (MtT/Se) established from an E2-induced mammotropic pituitary tumor. E2 stimulated cell growth 2-3 fold as compared to the control. Basic fibroblast growth factor (bFGF) stimulated cell growth in the presence of E2 (10(-9) M) but not in the absence of E2. Tamoxifen as an antiestrogen agent inhibited the proliferation of MtT/Se cells which had been treated with E2 or E2 and bFGF. Numbers of FGFR in E2-stimulated MtT/Se cells significantly exceeded those in cells not treated with E2. These observations indicate that E2 plays an important role in the regulation of FGFR induction in the anterior pituitary cells. |
| 巻・号 | 23(1-2) |
| ページ | 95-104 |
| 公開日 | 1997-1-1 |
| DOI | 10.1080/07435809709031845 |
| PMID | 9187541 |
| MeSH | Animals Cell Division / drug effects Drug Evaluation, Preclinical Estradiol / pharmacology* Fibroblast Growth Factor 2 / pharmacology Immunoblotting Pituitary Gland, Anterior / cytology Pituitary Gland, Anterior / drug effects* Pituitary Gland, Anterior / metabolism Rats Receptors, Fibroblast Growth Factor / biosynthesis* Tamoxifen / pharmacology Tumor Cells, Cultured |
| IF | 1.553 |
| 引用数 | 8 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM |
| リソース情報 | |
| ヒト・動物細胞 | MtT/Se(RCB0529) |