論文 - 詳細
| RRC ID | 39034 |
|---|---|
| 著者 | Nakajima K, Murakami M, Yanoshita R, Samejima Y, Karasawa K, Setaka M, Nojima S, Kudo I. |
| タイトル | Activated mast cells release extracellular type platelet-activating factor acetylhydrolase that contributes to autocrine inactivation of platelet-activating factor. |
| ジャーナル | J Biol Chem |
| Abstract |
IgE-dependent and -independent activation of mouse bone marrow-derived mast cells (BMMC) elicited rapid and transient production of platelet-activating factor (PAF), which reached a maximal level by 2-5 min and was then degraded rapidly, returning to base-line levels by 10-20 min. Inactivation of PAF was preceded by the release of PAF acetylhydrolase (PAF-AH) activity, which reached a plateau by 3-5 min and paralleled the release of beta-hexosaminidase, a marker of mast cell exocytosis. Immunochemical and molecular biological studies revealed that the PAF-AH released from activated mast cells was identical to the plasma-type isoform. In support of the autocrine action of exocytosed PAF-AH, adding exogenous recombinant plasma-type PAF-AH markedly reduced PAF accumulation in activated BMMC. Furthermore, culture of BMMC with a combination of c-kit ligand, interleukin-1beta and interleukin-10 for > 24 h led to an increase in plasma-type PAF-AH expression, accompanied by a reduction in stimulus-initiated PAF production. Collectively, these results suggest that plasma-type PAF-AH released from activated mast cells sequesters proinflammatory PAF produced by these cells, thereby revealing an intriguing anti-inflammatory aspect of mast cells. |
| 巻・号 | 272(32) |
| ページ | 19708-13 |
| 公開日 | 1997-8-8 |
| DOI | 10.1074/jbc.272.32.19708 |
| PII | S0021-9258(18)38838-0 |
| PMID | 9242626 |
| MeSH | 1-Alkyl-2-acetylglycerophosphocholine Esterase Animals Bone Marrow Cells Calcimycin / pharmacology Ionophores / pharmacology Kinetics Male Mast Cells / enzymology* Mast Cells / metabolism Mice Mice, Inbred BALB C Phospholipases A / metabolism* Platelet Activating Factor / metabolism* Polymerase Chain Reaction Rats Rats, Wistar Recombinant Proteins / metabolism Stem Cell Factor / metabolism beta-N-Acetylhexosaminidases / metabolism |
| IF | 4.238 |
| 引用数 | 34 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CHO-K1(RCB0285) |