論文 - 詳細
| RRC ID | 39134 |
|---|---|
| 著者 | Sato T, Hashizume M, Hotta Y, Okahata Y. |
| タイトル | Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions. |
| ジャーナル | Biometals |
| Abstract |
The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1 to S state. |
| 巻・号 | 11(2) |
| ページ | 107-12 |
| 公開日 | 1998-4-1 |
| DOI | 10.1023/a:1009273827598 |
| PMID | 9542064 |
| MeSH | Aluminum / pharmacology* Animals Cell Cycle / drug effects Cell Division / drug effects Cell Size / drug effects Cytoskeleton / drug effects HeLa Cells Humans Kinetics Melanoma, Experimental / drug therapy* Melanoma, Experimental / pathology* Metals, Rare Earth / pharmacology* Mice Tumor Cells, Cultured |
| IF | 2.479 |
| 引用数 | 35 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB0459) |