RRC ID 39134
著者 Sato T, Hashizume M, Hotta Y, Okahata Y.
タイトル Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions.
ジャーナル Biometals
Abstract The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM. B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions. B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1 to S state.
巻・号 11(2)
ページ 107-12
公開日 1998-4-1
DOI 10.1023/a:1009273827598
PMID 9542064
MeSH Aluminum / pharmacology* Animals Cell Cycle / drug effects Cell Division / drug effects Cell Size / drug effects Cytoskeleton / drug effects HeLa Cells Humans Kinetics Melanoma, Experimental / drug therapy* Melanoma, Experimental / pathology* Metals, Rare Earth / pharmacology* Mice Tumor Cells, Cultured
IF 2.479
引用数 35
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
ヒト・動物細胞 Hep G2(RCB0459)