RRC ID 39154
著者 Morizane M, Kawasaki Y, Miura T, Yagi K, Esumi S, Kitamura Y, Sendo T.
タイトル Photoinitiator-Initiated Estrogenic Activity in Human Breast Cancer Cell Line MCF-7.
ジャーナル J Toxicol Environ Health A
Abstract A recent in vitro study reported that the photoinitiator 2-isopropylthioxanthone (2-ITX) is an endocrine-disrupting compound (EDC). However, it is not clear whether other photoinitiators such as 1-hydroxycyclohexyl phenyl ketone (1-HCHPK) and 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MTMP) produce endocrine-disrupting effects. The purpose of this study was thus to assess the association between estrogenic activity and exposure to photoinitiators. For estimation of the proliferative effect of the photoinitiators, the E-screen assay was used. Six photoinitiators, 2,2-dimethoxy-2-phenylacetophenone (2,2-DMPAP), 2-ethylhexyl 4-(dimethylamino)benzoate (2-EHDAB), 1-HCHPK, 2-ITX, methyl-2-benzoylbenzoate (MBB), and MTMP, significantly increased number of MCF-7 cells, an estrogen-sensitive human breast cancer cell line. In addition, pretreatment with estrogen receptor (ER) antagonists such as clomiphene, tamoxifen, or fulvestrant, significantly reversed the proliferative effect of each photoinitiator. Data demonstrated that the six photoinitiators produced endocrine-disrupting effects and that these photoinitiators interacted with ER as agonists. Evidence indicates that the six photoinitiators demonstrated estrogenic activity via ER as agonists.
巻・号 78(23-24)
ページ 1450-60
公開日 2015-1-1
DOI 10.1080/15287394.2015.1094431
PMID 26692070
MeSH Endocrine Disruptors / toxicity* Female Humans MCF-7 Cells
IF 2.653
引用数 6
WOS 分野 ENVIRONMENTAL SCIENCES PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH TOXICOLOGY
リソース情報
ヒト・動物細胞 MCF7(RCB1904)