RRC ID |
39155
|
著者 |
Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.
|
タイトル |
Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.
|
ジャーナル |
Int J Oncol
|
Abstract |
Tropomodulin1 (TMOD1), which regulates the length and depolymerization of actin filaments by binding to the pointed end of the actin filament, has been reported to be a powerful diagnostic marker for ALK-negative anaplastic large-cell lymphoma; however, little is known about the relevance of TMOD1 in the behavior of oral squamous cell carcinoma (OSCC). We evaluated TMOD1 expression in OSCC-derived cell lines and primary OSCC samples (n=200) using quantitative reverse transcriptase-polymerase chain reaction, immunoblotting and semi-quantitative immunohistochemistry. We also analyzed the clinical correlation between TMOD1 expression status and clinical parameters in patients with OSCC and performed a prospective study using 40 primary OSCC samples. TMOD1 expression was upregulated significantly (p<0.05) in OSCC in vitro and in vivo compared with normal counterparts. TMOD1 expression also was correlated significantly (p=0.0199 and p=0.0064, respectively) with regional lymph node metastasis (RLNM) and 5-year survival rates. This prospective study also showed that high TMOD1 expression was seen in 12 (75%) of 16 cases in RLNM-positive patients and 9 (37.5%) of 24 cases in RLNM-negative patients. The current data provide the first evidence that TMOD1 expression is a critical biomarker for RLNM and prognosis of patients with OSCC.
|
巻・号 |
48(2)
|
ページ |
607-12
|
公開日 |
2016-2-1
|
DOI |
10.3892/ijo.2015.3305
|
PMID |
26718916
|
MeSH |
Actin Cytoskeleton / genetics
Aged
Carcinoma, Squamous Cell / genetics
Carcinoma, Squamous Cell / pathology
Female
Humans
Immunohistochemistry / methods
Lymph Nodes / pathology*
Lymphatic Metastasis / genetics*
Lymphatic Metastasis / pathology*
Lymphoma, Large-Cell, Anaplastic / genetics
Lymphoma, Large-Cell, Anaplastic / pathology
Male
Mouth Neoplasms / genetics*
Mouth Neoplasms / pathology*
Prognosis
Prospective Studies
Tropomodulin / genetics*
|
IF |
3.899
|
引用数 |
8
|
WOS 分野
|
ONCOLOGY
|
リソース情報 |
ヒト・動物細胞 |
HSC-4(RCB1902)
HSC-2(RCB1945)
HSC-3(RCB1975)
Sa3(RCB0980)
SAS(RCB1974)
Ca9-22(RCB1976)
HO-1-u-1(RCB2102) |