Reference - Detail
| RRC ID | 39222 |
|---|---|
| Author | Kataoka H, Joh T, Kasugai K, Okayama N, Moriyama A, Asai K, Kato T. |
| Title | Expression of mRNA for heregulin and its receptor, ErbB-3 and ErbB-4, in human upper gastrointestinal mucosa. |
| Journal | Life Sci |
| Abstract |
Expression of mRNA for heregulin (HRG), a member of the epidermal growth factor (EGF) family and its receptors, ErbB-3 and ErbB-4, were evaluated in human upper gastrointestinal (GI) mucosa. Multi-target reverse-transcriptase polymerase chain reaction (RT-PCR) analysis using capillary electrophoresis and laser-induced fluorescence allowed us to quantify the minute amounts of mRNA from one biopsy specimen with high sensitivity. HRG, ErbB-3 and ErbB-4 mRNA were detected in esophagus, stomach and duodenum and the highest expression was found in duodenum. In gastric cancer, mRNA for ErbB-4 was significantly overexpressed. Immunoreactivity of ErbB-4 in carcinoma cell membrane was also confirmed. These findings suggest that HRG and its receptors, ErbB-3 and ErbB-4 may be physiologically significant in the human upper GI mucosa, especially in duodenum, and that ErbB-4 may contribute to the growth of gastric cancer. |
| Volume | 63(7) |
| Pages | 553-64 |
| Published | 1998-1-1 |
| DOI | 10.1016/s0024-3205(98)00306-3 |
| PII | S0024320598003063 |
| PMID | 9718081 |
| MeSH | ErbB Receptors / genetics* Glycoproteins / genetics* Humans Intestinal Mucosa / metabolism* Nerve Growth Factors / genetics* Neuregulins Oligonucleotides, Antisense / metabolism Proto-Oncogene Proteins / genetics* RNA, Messenger / metabolism* Receptor, ErbB-3 Receptor, ErbB-4 Tumor Cells, Cultured |
| IF | 3.647 |
| Times Cited | 41 |
| WOS Category | PHARMACOLOGY & PHARMACY MEDICINE, RESEARCH & EXPERIMENTAL |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MKN45(RCB1001) MKN74(RCB1002) |