| RRC ID |
39240
|
| Author |
Tanaka T, Umesaki N, Mizuno K, Chang L, Ohtaki S, Ogita S.
|
| Title |
Enhancement of apoptotic susceptibility by interleukin-1 beta in human endometrial epithelial cells.
|
| Journal |
Gynecol Endocrinol
|
| Abstract |
Interleukin-1 (IL-1) is considered to be an essential cytokine for embryonic implantation. Expression of the IL-1 receptor in endometrial luminal epithelium increases maximally in the peri-implantation period, and embryonic implantation in mice is blocked by the IL-1 receptor antagonist. However, the function of IL-1 alone in implantation is still unclear. It has been reported that endometrial epithelial cells undergo apoptosis at the implantation site. In this study we have investigated the regulatory function of IL-1 in endometrial epithelial apoptosis, using the human endometrial epithelial cell line HHUA, which is susceptible to Fas-mediated apoptosis. The enhancement of endometrial apoptosis by IL-1 beta was not accompanied by any increase in cell-surface expression of Fas, which suggested that IL-1 beta enhanced the postreceptor apoptotic signals in the activated cells. IL-1 may be a regulator of apoptotic susceptibility in endometrial epithelium in the peri-implantation period.
|
| Volume |
12(5)
|
| Pages |
315-9
|
| Published |
1998-10-1
|
| DOI |
10.3109/09513599809012832
|
| PMID |
9859023
|
| MeSH |
Adenocarcinoma
Animals
Apoptosis*
Cell Division
DNA Fragmentation
Endometrial Neoplasms
Endometrium / cytology
Endometrium / metabolism*
Epithelial Cells / metabolism
Female
Flow Cytometry
Humans
Interleukin-1 / metabolism*
Mice
Receptors, Interleukin-1 / antagonists & inhibitors*
Tumor Cells, Cultured
|
| IF |
1.571
|
| Times Cited |
14
|
|
WOS Category
|
OBSTETRICS & GYNECOLOGY
ENDOCRINOLOGY & METABOLISM
|
| Resource |
| Human and Animal Cells |
HHUA(RCB0658) |
