論文 - 詳細
| RRC ID | 39263 |
|---|---|
| 著者 | Yoshida A, Minowa MT, Takamatsu S, Hara T, Ikenaga H, Takeuchi M. |
| タイトル | A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment. |
| ジャーナル | Glycoconj J |
| Abstract |
We isolated a novel cDNA encoding a second isoenzyme of UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase (GnT-IV; EC 2.4.1.145). The nucleotide and deduced amino acid sequences of the cDNA were homologous to those of the previously cloned human GnT-IV cDNA (63% and 62% identity, respectively). The new cDNA is also confirmed to express GnT-IV activity, suggesting that two isoenzymes of human GnT-IV exist. Although genomic Southern analysis suggested that both genes exist in many mammalian species and the chicken, northern analysis revealed that both genes are expressed in different ways in human tissues. This is the first report concerning the gene family of an N-acetylglucosaminyltransferase in mammals. |
| 巻・号 | 15(12) |
| ページ | 1115-23 |
| 公開日 | 1998-12-1 |
| DOI | 10.1023/a:1006951519522 |
| PMID | 10372966 |
| MeSH | Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Southern COS Cells Chromosome Mapping Chromosomes, Human, Pair 5* Cloning, Molecular DNA Primers DNA, Complementary Humans Isoenzymes / genetics* Molecular Sequence Data N-Acetylglucosaminyltransferases / genetics* Sequence Homology, Amino Acid Tumor Cells, Cultured |
| IF | 2.197 |
| 引用数 | 27 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | COS-7(RCB0539) |