Reference - Detail
| RRC ID | 39310 |
|---|---|
| Author | Tani K, Oyama Y, Hatsuzawa K, Tagaya M. |
| Title | Hypothetical protein KIAA0079 is a mammalian homologue of yeast Sec24p. |
| Journal | FEBS Lett |
| Abstract |
The Sec23p-Sec24p complex is a component of COPII-coated vesicles that mediate protein transport from the endoplasmic reticulum in yeast. The mammalian hypothetical protein KIAA0079 (KIAA0079p) exhibits sequence similarity to yeast Sec24p. KIAA0079p was co-eluted with mammalian Sec23p on gel filtration. In vitro binding experiments revealed that the C-terminal region of KIAA0079p binds to the N-terminal region of mammalian Sec23p. Overexpression of KIAA0079p caused a defect in protein export from the endoplasmic reticulum. These results support the idea that KIAA0079p is a functional homologue of yeast Sec24p. |
| Volume | 447(2-3) |
| Pages | 247-50 |
| Published | 1999-3-26 |
| DOI | 10.1016/s0014-5793(99)00303-8 |
| PII | S0014-5793(99)00303-8 |
| PMID | 10214955 |
| MeSH | Animals Binding Sites Biological Transport, Active Cell Line Chlorocebus aethiops Endoplasmic Reticulum / metabolism Fungal Proteins / chemistry Fungal Proteins / genetics Fungal Proteins / metabolism* Humans In Vitro Techniques Membrane Proteins / chemistry Membrane Proteins / genetics Membrane Proteins / metabolism* Proteins / chemistry Proteins / isolation & purification Proteins / metabolism Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / metabolism Saccharomyces cerevisiae Proteins* Transfection Vero Cells Vesicular Transport Proteins |
| IF | 3.057 |
| Times Cited | 9 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | Vero(RCB0001) |