| RRC ID |
39364
|
| Author |
Aramaki Y, Takano S, Tsuchiya S.
|
| Title |
Induction of apoptosis in macrophages by cationic liposomes.
|
| Journal |
FEBS Lett
|
| Abstract |
The effects of liposomes on apoptosis in macrophages were evaluated from DNA content and DNA fragmentation. Cationic liposomes composed of different kinds of cationic lipids induced apoptosis in mouse splenic macrophages and the macrophage-like cell line, RAW264.7 cells. Generation of reactive oxygen radicals from macrophages treated with cationic liposomes was detected using flow cytometry, and further apoptosis was inhibited by the addition of oxidant scavenger, N-acetylcysteine. From these findings, the production of reactive oxygen species may be important in the regulation of apoptosis induced by cationic liposomes.
|
| Volume |
460(3)
|
| Pages |
472-6
|
| Published |
1999-11-5
|
| DOI |
10.1016/s0014-5793(99)01386-1
|
| PII |
S0014-5793(99)01386-1
|
| PMID |
10556519
|
| MeSH |
Acetylcysteine / pharmacology
Animals
Apoptosis* / drug effects
Apoptosis* / genetics
Carcinoma, Hepatocellular
Cations
Cell Line
DNA / drug effects
DNA / metabolism
DNA Fragmentation / drug effects
DNA Fragmentation / genetics
Humans
Liposomes / metabolism
Liposomes / physiology*
Liver Neoplasms
Macrophages / cytology*
Macrophages / metabolism
Macrophages / physiology*
Mice
Mice, Inbred BALB C
Peroxides / metabolism
Rats
Rats, Wistar
Reactive Oxygen Species / physiology
Tumor Cells, Cultured
|
| IF |
3.057
|
| Times Cited |
70
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535)
Hep G2(RCB0459) |
