論文 - 詳細
| RRC ID | 39373 |
|---|---|
| 著者 | Yoshida K, Watanabe M, Kato H, Dutta A, Sugano S. |
| タイトル | BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain. |
| ジャーナル | FEBS Lett |
| Abstract |
Using a yeast two-hybrid system, we isolated eight cDNA clones which interacted with BH-protocadherin-c (BH-Pcdh-c) from the human brain cDNA library. One clone encoded protein phosphatase type I isoform alpha (PP1alpha) and another two PP1alpha2. PP1alpha was co-immunoprecipitated from the extract of a gastric adenocarcinoma cell line MKN-28 with anti-BH-Pcdh-c antibody. PP1alpha activity towards glycogen phosphorylase was inhibited by the intracellular domain of BH-Pcdh-c. Inhibition of the phosphatase required more than the minimal domain of BH-Pcdh-c which could associate with PP1alpha. In situ hybridization revealed that BH-Pcdh-c mRNA was predominantly expressed in cerebral cortex neurons in the adult mouse brain. |
| 巻・号 | 460(1) |
| ページ | 93-8 |
| 公開日 | 1999-10-22 |
| DOI | 10.1016/s0014-5793(99)01309-5 |
| PII | S0014-5793(99)01309-5 |
| PMID | 10571067 |
| MeSH | Animals Brain / metabolism Cadherins / metabolism* Cerebral Cortex / metabolism Cloning, Molecular Humans In Situ Hybridization Male Mice Mice, Inbred C57BL Molecular Sequence Data Oligonucleotides, Antisense Phosphoprotein Phosphatases / antagonists & inhibitors Phosphoprotein Phosphatases / metabolism* Phosphorylases / metabolism Precipitin Tests Protein Binding Protein Phosphatase 1 Protocadherins RNA, Messenger / metabolism Tumor Cells, Cultured Yeasts |
| IF | 3.057 |
| 引用数 | 48 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LTK-(RCB0208) |