| RRC ID |
39373
|
| 著者 |
Yoshida K, Watanabe M, Kato H, Dutta A, Sugano S.
|
| タイトル |
BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain.
|
| ジャーナル |
FEBS Lett
|
| Abstract |
Using a yeast two-hybrid system, we isolated eight cDNA clones which interacted with BH-protocadherin-c (BH-Pcdh-c) from the human brain cDNA library. One clone encoded protein phosphatase type I isoform alpha (PP1alpha) and another two PP1alpha2. PP1alpha was co-immunoprecipitated from the extract of a gastric adenocarcinoma cell line MKN-28 with anti-BH-Pcdh-c antibody. PP1alpha activity towards glycogen phosphorylase was inhibited by the intracellular domain of BH-Pcdh-c. Inhibition of the phosphatase required more than the minimal domain of BH-Pcdh-c which could associate with PP1alpha. In situ hybridization revealed that BH-Pcdh-c mRNA was predominantly expressed in cerebral cortex neurons in the adult mouse brain.
|
| 巻・号 |
460(1)
|
| ページ |
93-8
|
| 公開日 |
1999-10-22
|
| DOI |
10.1016/s0014-5793(99)01309-5
|
| PII |
S0014-5793(99)01309-5
|
| PMID |
10571067
|
| MeSH |
Animals
Brain / metabolism
Cadherins / metabolism*
Cerebral Cortex / metabolism
Cloning, Molecular
Humans
In Situ Hybridization
Male
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Oligonucleotides, Antisense
Phosphoprotein Phosphatases / antagonists & inhibitors
Phosphoprotein Phosphatases / metabolism*
Phosphorylases / metabolism
Precipitin Tests
Protein Binding
Protein Phosphatase 1
Protocadherins
RNA, Messenger / metabolism
Tumor Cells, Cultured
Yeasts
|
| IF |
3.057
|
| 引用数 |
48
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
|
