| RRC ID |
39401
|
| Author |
Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T.
|
| Title |
Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene.
|
| Journal |
FEBS Lett
|
| Abstract |
A novel human homologue (GCMB) of the Drosophila glial cells missing gene (dGCM) was isolated using RACE. GCMB contained a gcm motif sequence and a nuclear targeting sequence similar to that of dGCM and mouse GCMb. Homology searches indicated that GCMB was located within chromosome 6p24.2. Transcripts of GCMB were detected by means of RT-PCR in fetal brain, normal adult kidney, 3/3 medulloblastomas, 1/3 gliomas and 4/8 non-neuroepithelial tumor cell lines. Our data suggest that humans have two homologues of gcm like mice and that human gcm genes form a novel family which may function not only during fetal development but also in the postnatal or pathological stage.
|
| Volume |
442(2-3)
|
| Pages |
151-6
|
| Published |
1999-1-15
|
| DOI |
10.1016/s0014-5793(98)01650-0
|
| PII |
S0014-5793(98)01650-0
|
| PMID |
9928992
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Brain / embryology
Brain / metabolism*
Chromosomes, Human, Pair 6 / genetics
Cloning, Molecular*
DNA-Binding Proteins
Drosophila Proteins
Drosophila melanogaster / genetics
Expressed Sequence Tags
Gene Expression*
Gene Library
Humans
Kidney / metabolism
Molecular Sequence Data
Neoplasms, Neuroepithelial / metabolism
Neuropeptides / chemistry
Neuropeptides / genetics*
Polymerase Chain Reaction
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Trans-Activators / chemistry
Trans-Activators / genetics*
Transcription Factors
Tumor Cells, Cultured
|
| IF |
3.057
|
| Times Cited |
45
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
U251(RCB0461) |
