Reference - Detail
| RRC ID | 39420 |
|---|---|
| Author | Yoshiko Y, Son A, Maeda S, Igarashi A, Takano S, Hu J, Maeda N. |
| Title | Evidence for stanniocalcin gene expression in mammalian bone. |
| Journal | Endocrinology |
| Abstract |
Stanniocalcin (STC) acts as a regulator of calcium and phosphate homeostasis in an endocrine manner in bony fish. Recently, complementary DNAs encoding human and mouse STC have been characterized, and the messenger RNA (mRNA) expression was identified in various tissues, such as kidney, small intestine, prostate, thyroid, and ovary. Because previous studies concerning the effects of fish STC on mammalian bone have been discussed, there is a good possibility that mammalian STC is a local factor in bone. Here, we demonstrated STC mRNA expression in neonatal mouse calvaria, the primary cultured mouse osteoblast-rich fractions, and human and mouse osteoblastic cell lines. We also mapped the cellular distribution of the STC mRNA in femur and calvaria in developing mice. Several transcripts with a major 4-kb band were detected in all samples. The cellular distribution of the mRNA expression corresponded closely to osteoblasts in both femur and calvaria. Significant labeling of the STC mRNA was also identified in chondrocytes but not in osteoclasts and other bone marrow elements. These results are the first evidence that hormone may be actually expressed in osteoblasts and chondrocytes, and they strongly implicate the involvement of local STC in both endochondral and membrane bone as an autocrine/paracrine factor. |
| Volume | 140(4) |
| Pages | 1869-74 |
| Published | 1999-4-1 |
| DOI | 10.1210/endo.140.4.6662 |
| PMID | 10098526 |
| MeSH | Aging Animals Animals, Newborn Blotting, Northern Bone and Bones / chemistry* Cells, Cultured Chondrocytes / chemistry Femur Gene Expression* Glycoproteins / genetics* Hormones / genetics* Humans Mice Osteoblasts / chemistry Osteosarcoma RNA, Messenger / analysis Tumor Cells, Cultured |
| IF | 3.934 |
| Times Cited | 37 |
| WOS Category | ENDOCRINOLOGY & METABOLISM |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HOS(RCB0992) |