| RRC ID |
39431
|
| 著者 |
Ichino N, Ishiguro H, Yamada K, Nishii K, Sawada H, Nagatsu T.
|
| タイトル |
Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells.
|
| ジャーナル |
Neurosci Res
|
| Abstract |
The influence of nicotine on the expression of Fos family proteins, which specifically formed complexes with the AP-1 sequence, was assessed. mRNA for c-Fos, c-jun and jun-B were up-regulated at 0.5 h after nicotine treatment, elevated c-Fos also being apparent after withdrawal. Although nicotine failed to up-regulate the mRNA level of the fra-1 gene, the Fra- protein was highly expressed after both treatment and withdrawal. These results indicate that nicotine treatment may affect the transcriptional activity of many genes through c-Fos and c-Jun protein expression in neural cells, and that Fra-1 protein may make a contribution. These changes in immediately early genes (IEGs) may be associated with nicotine withdrawal symptoms.
|
| 巻・号 |
35(1)
|
| ページ |
63-9
|
| 公開日 |
1999-10-1
|
| DOI |
10.1016/s0168-0102(99)00069-3
|
| PII |
S0168-0102(99)00069-3
|
| PMID |
10555165
|
| MeSH |
Adrenal Gland Neoplasms
Amino Acid Sequence
Animals
Antisense Elements (Genetics)
Gene Expression Regulation, Neoplastic / drug effects
Gene Expression Regulation, Neoplastic / physiology*
Genes, fos*
Genes, jun
Humans
Mice
Molecular Sequence Data
Nicotine / pharmacology*
Oligonucleotide Probes
PC12 Cells
Pheochromocytoma
Proto-Oncogene Proteins c-fos / chemistry
Proto-Oncogene Proteins c-fos / genetics*
Proto-Oncogene Proteins c-jun / genetics
RNA, Messenger / genetics
Rats
Sequence Alignment
Sequence Homology, Amino Acid
Substance Withdrawal Syndrome
Transcription, Genetic / drug effects
|
| IF |
2.645
|
| 引用数 |
10
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ヒト・動物細胞 |
|
