RRC ID 39463
著者 Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M, Takemura Y, Ju-ichi M, Ito C, Furukawa H.
タイトル The antiproliferative effect of acridone alkaloids on several cancer cell lines.
ジャーナル J Nat Prod
Abstract Fifteen acridone alkaloids were examined for their antiproliferative activity toward monolayers and suspension of several types of cancer and normal human cell lines. As a result, atalaphyllidine (9), 5-hydroxy-N-methylseverifoline (11), atalaphyllinine (12), and des-N-methylnoracronycine (13) showed potent antiproliferative activity against tumor cell lines, whereas they have weak cytotoxicity on normal human cell lines. The structure-activity relationship established from the results revealed that a secondary amine, hydroxyl groups at C-1 and C-5, and a prenyl group at C-2 played an important role for antiproliferative activities of the tetracyclic acridones.
巻・号 62(4)
ページ 587-9
公開日 1999-4-1
DOI 10.1021/np980504z
PII np980504z
PMID 10217715
MeSH Acridines / chemistry Acridines / isolation & purification Acridines / pharmacology* Acridones Alkaloids / chemistry Alkaloids / isolation & purification Alkaloids / pharmacology* Animals Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology* Cell Division / drug effects Drug Screening Assays, Antitumor Humans Inhibitory Concentration 50 Mice Structure-Activity Relationship Tumor Cells, Cultured
IF 3.782
引用数 44
WOS 分野 PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL PLANT SCIENCES
リソース情報
ヒト・動物細胞 A549(RCB0098) B16 melanoma 4A5(RCB0557) CCRF-HSB-2(RCB0016) TGBC11TKB(RCB1148)