論文 - 詳細
| RRC ID | 39470 |
|---|---|
| 著者 | Agungpriyono DR, Yamaguchi R, Tohya Y, Uchida K, Tateyama S. |
| タイトル | Pathogenicity of Sendai viruses adapted into polarized MDCK cells. |
| ジャーナル | J Vet Med Sci |
| Abstract |
Apically and basally released Sendai viruses (SeV) were obtained after infection of polarized Madin-Darby canine kidney (MDCK) cells grown on permeable membrane culture inserts. After 20 passages of adaptation in MDCK cells, we compared their in vivo and in vitro pathogenicity with the parental Mol-strain of SeV. These viruses had comparable in vitro pathogenicity, but the in vivo pathogenicities were varied. The apically released MDCK-adapted virus showed comparable pathogenicity with the parental virus, in contrast with the basally released MDCK-adapted virus, which showed in vivo attenuation. |
| 巻・号 | 61(12) |
| ページ | 1299-307 |
| 公開日 | 1999-12-1 |
| DOI | 10.1292/jvms.61.1299 |
| PMID | 10651050 |
| MeSH | Animals Antigens, Viral / immunology Biological Assay Cells, Cultured Chick Embryo Dogs Epithelial Cells Female Hemagglutination Tests Immunohistochemistry Kidney / cytology Kidney / virology Lung / pathology Lung / virology Mice Mice, Inbred ICR Polymers Respirovirus / immunology Respirovirus / pathogenicity* Respirovirus Infections / immunology Respirovirus Infections / pathology Respirovirus Infections / virology* Specific Pathogen-Free Organisms Viral Plaque Assay Virulence Virus Replication |
| IF | 1.049 |
| 引用数 | 2 |
| WOS 分野 | VETERINARY SCIENCES |
| リソース情報 | |
| ヒト・動物細胞 | MDCK(RCB0995) |