Reference - Detail
| RRC ID | 39481 |
|---|---|
| Author | Koike E, Kobayashi T, Murakami M, McWilliam AS, Holt PG. |
| Title | Mechanisms of ozone-induced inhibitory effect of bronchoalveolar lavage fluid on alveolar macrophage-mediated immunosuppressive activity in rats. |
| Journal | J Leukoc Biol |
| Abstract |
Resident alveolar macrophages (AM) play an important immunomodulatory role via suppression of lymphocyte proliferation, and nitric oxide (NO) plays a crucial role in this immunosuppression of AM. Our previous report suggested that during ozone (O3)-induced lung inflammation, bronchoalveolar lavage fluid (BALF) inhibited AM-mediated immunosuppression and concanavalin A (Con A)-induced proliferation of lymph node cells (LNC) [E. Koike et al. (1998) Toxicol. Sci. 41, 217-223]. In these studies, we investigated the mechanisms of the inhibition of BALF from O3-exposed rats (O3-BALF). We investigated whether BALF might affect (1) the interferon-gamma (IFN-gamma) production by Con A-stimulated LNC and IFN-gamma-induced NO production by AM, and (2) the interleukin (IL)-2 production by Con A-stimulated LNC and IL-2-induced LNC proliferation. These results demonstrated that O3-BALF inhibited IFN-gamma production by Con A-stimulated LNC, IFN-gamma-induced NO production by AM, and IL-2-induced LNC proliferation. In addition, the major inhibitory factor against AM-mediated immunosuppression in O3-BALF may be a protein of greater than 10 kDa. |
| Volume | 66(1) |
| Pages | 75-82 |
| Published | 1999-7-1 |
| DOI | 10.1002/jlb.66.1.75 |
| PMID | 10410992 |
| MeSH | Animals Bronchoalveolar Lavage Fluid Cell Division Concanavalin A / pharmacology Immune Tolerance / immunology* Interferon-gamma / immunology Lymph Nodes / cytology Macrophages, Alveolar / immunology* Male Mitogens / pharmacology Neutralization Tests Nitric Oxide / metabolism Ozone / immunology* Rats Rats, Wistar |
| IF | 3.757 |
| Times Cited | 7 |
| WOS Category | HEMATOLOGY IMMUNOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | CTLL-2(RCB0637) |