| RRC ID |
39530
|
| Author |
Ogata S, Miyake Y, Yamamoto K, Okumura K, Taguchi H.
|
| Title |
Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes.
|
| Volume |
64(5)
|
| Pages |
1075-8
|
| Published |
2000-5-1
|
| DOI |
10.1271/bbb.64.1075
|
| PMID |
10879486
|
| MeSH |
Apoptosis / drug effects
Apoptosis / physiology*
Caffeic Acids / pharmacology
Caspase Inhibitors
Cell Size
Citrus / chemistry*
DNA Fragmentation / drug effects
Dose-Response Relationship, Drug
Electrophoresis, Agar Gel
Flavanones*
Flavonoids / chemistry
Flavonoids / metabolism*
Flavonoids / pharmacology*
HL-60 Cells
Hesperidin / analogs & derivatives*
Hesperidin / pharmacology
Humans
Phloroglucinol / pharmacology
|
| IF |
1.516
|
| Times Cited |
30
|
|
WOS Category
|
CHEMISTRY, APPLIED
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
HL60(RCB0041) |
