論文 - 詳細
| RRC ID | 39530 |
|---|---|
| 著者 | Ogata S, Miyake Y, Yamamoto K, Okumura K, Taguchi H. |
| タイトル | Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes. |
| 巻・号 | 64(5) |
| ページ | 1075-8 |
| 公開日 | 2000-5-1 |
| DOI | 10.1271/bbb.64.1075 |
| PMID | 10879486 |
| MeSH | Apoptosis / drug effects Apoptosis / physiology* Caffeic Acids / pharmacology Caspase Inhibitors Cell Size Citrus / chemistry* DNA Fragmentation / drug effects Dose-Response Relationship, Drug Electrophoresis, Agar Gel Flavanones* Flavonoids / chemistry Flavonoids / metabolism* Flavonoids / pharmacology* HL-60 Cells Hesperidin / analogs & derivatives* Hesperidin / pharmacology Humans Phloroglucinol / pharmacology |
| IF | 1.516 |
| 引用数 | 30 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HL60(RCB0041) |