Reference - Detail
| RRC ID | 39531 |
|---|---|
| Author | Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H. |
| Title | Apoptosis induced by niacin-related compounds in K562 cells but not in normal human lymphocytes. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
In our previous study, we found that niacin-related compounds induced apoptosis in human acute myelomonocytic leukemia cells, HL-60. We have investigated whether these compounds acted as inducers of apoptosis also in various other cell types. In human chronic myelogenous leukemia cells, K562, which are relatively resistant to various inducers of apoptosis, the apoptosis was induced by picolinic acid and dipicolinic acid in about 50% of the cells 5-10 mM via the caspase pathway, but was not at 1 mM. However, isonicotinamide did not induce apoptosis effectively in K562 cells. On the other hand, in normal human quiescent lymphocytes, the apoptosis was not induced by these compounds at the same concentrations. It is suggested that these compounds may induce apoptosis mainly in tumor cells. The change of intracellular peroxide levels was observed in the early phase of apoptosis induced by niacin-related compounds. We expect to make use of niacin-related compounds in the field of medicine. |
| Volume | 64(6) |
| Pages | 1142-6 |
| Published | 2000-6-1 |
| DOI | 10.1271/bbb.64.1142 |
| PMID | 10923782 |
| MeSH | Antineoplastic Agents / pharmacology Apoptosis / drug effects* Humans K562 Cells Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology Lymphocytes / cytology* Lymphocytes / drug effects* Lymphocytes / metabolism Niacin / analogs & derivatives* Niacin / pharmacology Niacinamide / pharmacology Peroxides / metabolism Picolinic Acids / pharmacology Reactive Oxygen Species / metabolism |
| IF | 1.516 |
| Times Cited | 15 |
| WOS Category | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |