| RRC ID |
39610
|
| 著者 |
Kataoka H, Itoh H, Uchino H, Hamasuna R, Kitamura N, Nabeshima K, Koono M.
|
| タイトル |
Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
Hepatocyte growth factor activator inhibitor type 2 (HAI-2) was recently identified as a potent inhibitor of hepatocyte growth factor activator. It was also independently reported as placental bikunin (PB) and as a protein over-expressed in pancreatic cancer. The expression of HAI-2/PB was analyzed in human normal colon mucosa, adenomas, and carcinomas. HAI-2/PB mRNA was consistently expressed in the colorectal mucosa. The expression was conserved in the neoplastic colorectal mucosa, and no relationship was found between HAI-2/PB mRNA levels and tumor stages. Moreover, 13 out of 14 colorectal carcinoma cell lines expressed HAI-2/PB mRNA. Immunohistochemically, HAI-2/PB proteins were predominantly stained beneath the apical surface of normal enterocytes. In tumor tissues, rather disarranged intracytoplasmic granular staining was observed. The HAI-2/PB immunoreactivity was well conserved in the colonic adenoma-carcinoma sequence, and this protein may have important unknown function in the intestinal mucosa.
|
| 巻・号 |
148(2)
|
| ページ |
127-34
|
| 公開日 |
2000-2-1
|
| DOI |
10.1016/s0304-3835(99)00322-5
|
| PII |
S0304383599003225
|
| PMID |
10695988
|
| MeSH |
Adult
Aged
Aged, 80 and over
Animals
Cell Differentiation
Colon / metabolism
Colorectal Neoplasms / genetics
Colorectal Neoplasms / metabolism*
Colorectal Neoplasms / pathology
Female
Glycoproteins / biosynthesis*
Glycoproteins / genetics
Humans
Intestinal Mucosa / metabolism
Male
Membrane Glycoproteins / biosynthesis*
Membrane Glycoproteins / genetics
Mice
Mice, Inbred BALB C
Middle Aged
RNA, Messenger / biosynthesis
Serine Proteinase Inhibitors / biosynthesis*
Serine Proteinase Inhibitors / genetics
Trypsin Inhibitor, Kunitz Soybean*
|
| IF |
7.36
|
| 引用数 |
23
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
CW-2(RCB0778)
DLD-1(RCB1957) |
