RRC ID |
39643
|
著者 |
Hamada T, Ui-Tei K, Miyata Y.
|
タイトル |
A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family.
|
ジャーナル |
FEBS Lett
|
Abstract |
We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.
|
巻・号 |
475(2)
|
ページ |
97-102
|
公開日 |
2000-6-16
|
DOI |
10.1016/s0014-5793(00)01640-9
|
PII |
S0014-5793(00)01640-9
|
PMID |
10858496
|
MeSH |
Amino Acid Sequence
Animals
Blotting, Northern
CHO Cells
Cell Survival / drug effects
Chick Embryo
Cloning, Molecular
Cricetinae
DNA, Complementary / metabolism
Endothelial Growth Factors / genetics
Humans
Lymphokines / biosynthesis
Lymphokines / chemistry
Lymphokines / genetics*
Microscopy, Phase-Contrast
Molecular Sequence Data
Multigene Family
Platelet-Derived Growth Factor / biosynthesis
Platelet-Derived Growth Factor / chemistry
Platelet-Derived Growth Factor / genetics*
Protein Structure, Tertiary
RNA, Messenger / metabolism
Sequence Homology, Amino Acid
Spinal Cord / embryology
Spinal Cord / metabolism*
Time Factors
Transfection
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
|
IF |
3.057
|
引用数 |
18
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
ヒト・動物細胞 |
CHO-K1(RCB0285)
10T1/2(RCB0247) |