RRC ID 39643
Author Hamada T, Ui-Tei K, Miyata Y.
Title A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family.
Journal FEBS Lett
Abstract We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.
Volume 475(2)
Pages 97-102
Published 2000-6-16
DOI 10.1016/s0014-5793(00)01640-9
PII S0014-5793(00)01640-9
PMID 10858496
MeSH Amino Acid Sequence Animals Blotting, Northern CHO Cells Cell Survival / drug effects Chick Embryo Cloning, Molecular Cricetinae DNA, Complementary / metabolism Endothelial Growth Factors / genetics Humans Lymphokines / biosynthesis Lymphokines / chemistry Lymphokines / genetics* Microscopy, Phase-Contrast Molecular Sequence Data Multigene Family Platelet-Derived Growth Factor / biosynthesis Platelet-Derived Growth Factor / chemistry Platelet-Derived Growth Factor / genetics* Protein Structure, Tertiary RNA, Messenger / metabolism Sequence Homology, Amino Acid Spinal Cord / embryology Spinal Cord / metabolism* Time Factors Transfection Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
IF 2.675
Times Cited 18
Human and Animal Cells