論文 - 詳細
| RRC ID | 39643 |
|---|---|
| 著者 | Hamada T, Ui-Tei K, Miyata Y. |
| タイトル | A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. |
| ジャーナル | FEBS Lett |
| Abstract |
We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord. |
| 巻・号 | 475(2) |
| ページ | 97-102 |
| 公開日 | 2000-6-16 |
| DOI | 10.1016/s0014-5793(00)01640-9 |
| PII | S0014-5793(00)01640-9 |
| PMID | 10858496 |
| MeSH | Amino Acid Sequence Animals Blotting, Northern CHO Cells Cell Survival / drug effects Chick Embryo Cloning, Molecular Cricetinae DNA, Complementary / metabolism Endothelial Growth Factors / genetics Humans Lymphokines / biosynthesis Lymphokines / chemistry Lymphokines / genetics* Microscopy, Phase-Contrast Molecular Sequence Data Multigene Family Platelet-Derived Growth Factor / biosynthesis Platelet-Derived Growth Factor / chemistry Platelet-Derived Growth Factor / genetics* Protein Structure, Tertiary RNA, Messenger / metabolism Sequence Homology, Amino Acid Spinal Cord / embryology Spinal Cord / metabolism* Time Factors Transfection Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| IF | 3.057 |
| 引用数 | 18 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | CHO-K1(RCB0285) 10T1/2(RCB0247) |