論文 - 詳細
| RRC ID | 39799 |
|---|---|
| 著者 | Yamazaki R, Hatano H, Aiyama R, Matsuzaki T, Hashimoto S, Yokokura T. |
| タイトル | Diarylheptanoids suppress expression of leukocyte adhesion molecules on human vascular endothelial cells. |
| ジャーナル | Eur J Pharmacol |
| Abstract |
Diarylheptanoids possess potent anti-inflammatory properties. However, the mechanism of their action is not fully understood. In this study, we found that three diarylheptanoids, 1-(3, 5-dimethoxy-4-hydroxyphenyl)-7-phenylhept-1-en-3-one (YPE-01), yakuchinone B and demethyl-yakuchinone B, reduced the adhesion of both human monocytic cell line U937 and human eosinophilic cell line EoL-1 cells to tumor necrosis factor-alpha (TNF-alpha)-treated human umbilical vein endothelial cells. In addition, they suppressed interleukin-1beta- or TNF-alpha-induced expression of E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) on the surface of the endothelial cells. Since YPE-01 reduced both VCAM-1 and ICAM-1 mRNA induction in TNF-alpha-stimulated endothelial cells, diarylheptanoids appeared to suppress adhesion molecule expression at the transcriptional level. Furthermore, YPE-01 suppressed both VCAM-1 and ICAM-1 mRNA induction as well as edema in 12-O-tetradecanoylphorbol 13-acetate (TPA)-inflamed mice ears in vivo. These results suggest that the anti-inflammatory action of diarylheptanoids is, at least in part, due to their suppressive effect on the surface expression of inducible adhesion molecules in endothelial cells, and subsequent leukocyte adhesion. |
| 巻・号 | 404(3) |
| ページ | 375-85 |
| 公開日 | 2000-9-22 |
| DOI | 10.1016/s0014-2999(00)00620-8 |
| PII | S0014-2999(00)00620-8 |
| PMID | 10996603 |
| MeSH | Animals Cell Adhesion Molecules / drug effects* Cell Adhesion Molecules / metabolism Cells, Cultured Diarylheptanoids* E-Selectin / drug effects E-Selectin / metabolism Edema / drug therapy Edema / metabolism Endothelium, Vascular / drug effects* Endothelium, Vascular / metabolism Guaiacol / analogs & derivatives* Guaiacol / pharmacology Guaiacol / therapeutic use Humans Intercellular Adhesion Molecule-1 / drug effects Intercellular Adhesion Molecule-1 / metabolism Male Mice Mice, Inbred ICR Phytotherapy Plants, Medicinal / therapeutic use Tumor Cells, Cultured Tumor Necrosis Factor-alpha / pharmacology Umbilical Veins / drug effects Umbilical Veins / metabolism Vascular Cell Adhesion Molecule-1 / drug effects Vascular Cell Adhesion Molecule-1 / metabolism |
| IF | 3.263 |
| 引用数 | 16 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | EoL-1 cell(RCB0641) |