Reference - Detail
|Author||Goto S, Lin YC, Lai CY, Lee CM, Pan TL, Lord R, Chiang KC, Tseng HP, Lin CL, Cheng YF, Yokoyama H, Kitano S, Chen CL.|
|Title||Telomerase activity in rat liver allografts.|
BACKGROUND:Telomerase activity in grafts may be involved in the alteration of cellular senescence after transplantation or its relevant immunological events.
METHODS:At the age of 20 weeks, donor livers harvested from DA (RT1a) were orthotopically transplanted into PVG (RT1c) or LEW (RT1(1)) rats. Rats having undergone orthotopic liver transplantation (OLT; DA-PVG) naturally overcome rejection, whereas all OLT (DA-LEW) rats die from acute rejection within 14 days. Telomerase activity in liver allografts was measured at various intervals post OLT.
RESULTS:At day 7 when the most severe rejection episode was observed in OLT (DA-LEW) and OLT (DA-PVG), the telomerase activity was significantly higher than in syngeneic OLT (DA-DA) rats, in which no rejection occurred. Telomerase activity in tolerogenic OLT (DA-PVG) livers remained elevated for at least 2 months.
CONCLUSION:These results suggest that telomerase activity in allogeneic OLT livers may reflect regenerating hepatocytes or activation of lymphocytes and/or hematopoietic stem cells associated with rejection or tolerance.
|MeSH||Animals Graft Rejection / enzymology Liver / enzymology* Liver Transplantation* Rats Rats, Inbred Strains Telomerase / metabolism* Transplantation, Homologous Transplantation, Isogeneic|
|WOS Category||TRANSPLANTATION SURGERY IMMUNOLOGY|
|Human and Animal Cells|