論文 - 詳細
| RRC ID | 39918 |
|---|---|
| 著者 | Ogata S, Inoue K, Iwata K, Okumura K, Taguchi H. |
| タイトル | Apoptosis induced by picolinic acid-related compounds in HL-60 cells. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis. |
| 巻・号 | 65(10) |
| ページ | 2337-9 |
| 公開日 | 2001-10-1 |
| DOI | 10.1271/bbb.65.2337 |
| PMID | 11758936 |
| MeSH | Apoptosis / drug effects* DNA Fragmentation Flow Cytometry Fusaric Acid / pharmacology HL-60 Cells / drug effects* Humans Picolinic Acids / pharmacology* |
| IF | 1.516 |
| 引用数 | 22 |
| WOS 分野 | CHEMISTRY, APPLIED FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |