Reference - Detail
RRC ID | 39926 |
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Author | Wang HS, Wasa M, Okada A. |
Title | Regulation of glutamine transport by the type I insulin-like growth factor receptor in a human neuroblastoma cell line. |
Journal | Cancer Lett |
Abstract |
We examined the effects of the monoclonal antibody against the type I insulin-like growth factor receptor (IGF-IR), alphaIR3, on cell growth and membrane glutamine (Gln) transport in a human neuroblastoma cell line, SK-N-SH. In the presence of alphaIR3 (2 microg/ml), the cell proliferation rate was significantly attenuated. Gln transport was decreased in the alphaIR3-treated group with the mechanism of decreasing maximum transport velocity without affecting transport affinity. The addition of alphaIR3 significantly decreased DNA and protein biosynthesis. Our results support the concept that the activation of IGF-IR partially mediates neuroblastoma cell proliferation by regulating membrane Gln transport. |
Volume | 168(1) |
Pages | 81-6 |
Published | 2001-7-10 |
DOI | 10.1016/s0304-3835(01)00500-6 |
PII | S0304383501005006 |
PMID | 11368881 |
MeSH | Apoptosis Cell Division Cell Membrane / metabolism Dose-Response Relationship, Drug Glutamine / metabolism* Humans Leucine / metabolism Neuroblastoma / metabolism* Protein Transport* Receptor, IGF Type 1 / metabolism* Thymidine / metabolism Time Factors Tumor Cells, Cultured |
IF | 7.36 |
Times Cited | 1 |
WOS Category | ONCOLOGY |
Resource | |
Human and Animal Cells | SK-N-SH(RCB0426) |