論文 - 詳細
| RRC ID | 39960 |
|---|---|
| 著者 | Takahashi K, Totsune K, Murakami O, Sone M, Satoh F, Kitamuro T, Noshiro T, Hayashi Y, Sasano H, Shibahara S. |
| タイトル | Expression of melanin-concentrating hormone receptor messenger ribonucleic acid in tumor tissues of pheochromocytoma, ganglioneuroblastoma, and neuroblastoma. |
| ジャーナル | J Clin Endocrinol Metab |
| Abstract |
Expression of melanin-concentrating hormone (MCH) receptor messenger ribonucleic acid (mRNA) was studied by RT-PCR and Northern blot analysis in human brain; pituitary; adrenal glands; tumor tissues of adrenal tumors, ganglioneuroblastomas, and neuroblastomas; and various cultured tumor cell lines. RT-PCR analysis showed that MCH receptor mRNA was widely expressed in brain tissues, pituitary, normal portions of adrenal glands (cortex and medulla), tumor tissues of adrenocortical tumors (12 of 13 cases), pheochromocytoma (all 7 cases), ganglioneuroblastoma (1 case), neuroblastoma (all 5 cases), and various cultured tumor cell lines (6 of 7 cell lines), including 2 neuroblastoma cell lines. Northern blot analysis showed the expression of MCH receptor mRNA ( approximately 2.4 kb) only in the tumor tissues of 5 pheochromocytomas, 1 ganglioneuroblastoma, and 4 neuroblastomas, indicating that the expression levels of MCH receptor mRNA are much higher in these tumors than in the other tissues. These findings raised the possibility that MCH or MCH-like peptides may be related to the pathophysiology of these neural crest-derived tumors. |
| 巻・号 | 86(1) |
| ページ | 369-74 |
| 公開日 | 2001-1-1 |
| DOI | 10.1210/jcem.86.1.7158 |
| PMID | 11232026 |
| MeSH | Adrenal Gland Neoplasms / metabolism* Adrenal Glands / metabolism Blotting, Northern Brain / metabolism Ganglioneuroblastoma / metabolism* Humans Neuroblastoma / metabolism* Pheochromocytoma / metabolism* Pituitary Gland / metabolism RNA, Messenger / metabolism* Receptors, Pituitary Hormone / genetics* Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured |
| IF | 5.399 |
| 引用数 | 20 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | NB69(RCB0480) |