Reference - Detail
| RRC ID | 40011 |
|---|---|
| Author | Ho JCH, Hsiao CD, Kawakami K, Tse WKF. |
| Title | Triclosan (TCS) exposure impairs lipid metabolism in zebrafish embryos. |
| Journal | Aquat Toxicol |
| Abstract |
Triclosan (TCS) is an active antimicrobial ingredient used in many household products, such as skin creams and toothpaste. It is produced in high volumes, and humans are directly exposed to it and dispose it on a daily basis. TCS has been found to contaminate water worldwide. This study aimed to understand the potential developmental and metabolic abnormalities caused by TCS exposure by using zebrafish as the experimental model. Four developmental stages (70-85% epiboly, 10-12 somite, prim-5, and 5dpf) were selected to perform in situ hybridization staining to investigate the effects of TCS on dorsal ventral patterning, segmentation, brain development, and organ formation. Results showed, in terms of developmental toxicology, that neither phenotypic nor molecular changes were found after 5 days of 250μg/L TCS exposure. However, such dosage of TCS exposure resulted in lipid droplet accumulation in the yolk sac, which might due to the deregulated mRNA expression level of beta-oxidation transcripts. This study showed that 250μg/L TCS exposure does not affect normal embryogenesis or organogenesis; however, there are concerns regarding possible impairment of lipid metabolism. |
| Volume | 173 |
| Pages | 29-35 |
| Published | 2016-4-1 |
| DOI | 10.1016/j.aquatox.2016.01.001 |
| PII | S0166-445X(16)30001-7 |
| PMID | 26828895 |
| MeSH | Animals Lipid Metabolism / drug effects* Triclosan / toxicity* Water Pollutants, Chemical / toxicity Zebrafish / embryology* |
| IF | 4.346 |
| Times Cited | 44 |
| WOS Category | MARINE & FRESHWATER BIOLOGY TOXICOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | SAIGFF18A UAS:GFP |