RRC ID |
40053
|
著者 |
Matsuyama M, Haneda C, Kato K.
|
タイトル |
Congenic strain differences of renal malformations in ACI/Mna rats by introgression of the chromosomal region of BUF/Mna rats containing Pur1.
|
ジャーナル |
Nagoya J Med Sci
|
Abstract |
The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
|
巻・号 |
75(3-4)
|
ページ |
251-4
|
公開日 |
2013-8-1
|
PMID |
24640181
|
PMC |
PMC4345667
|
MeSH |
Animals
Animals, Congenic*
Chromosome Mapping / methods*
Chromosomes / ultrastructure*
Crosses, Genetic
Disease Models, Animal
Female
Hydronephrosis / genetics
Kidney / abnormalities*
Kidney Diseases / genetics*
Male
Rats
Rats, Inbred ACI
Rats, Inbred BUF
Rats, Inbred WKY
Species Specificity
|
IF |
0.762
|
引用数 |
0
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
|
リソース情報 |
ラット |
BUF/Mna (strainID=458) |