Reference - Detail
| RRC ID | 40064 |
|---|---|
| Author | Saito T, Itabashi T, Wakana D, Takeda H, Yaguchi T, Kawai K, Hosoe T. |
| Title | Isolation and structure elucidation of new phthalide and phthalane derivatives, isolated as antimicrobial agents from Emericella sp. IFM57991. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
Three new phthalide derivatives, emefuranones A1, A2 and B (1-3); six new phthalane derivatives, emefuran A, B1, B2, C1, C2 and D (4-9); three new farnesylated phthalide derivatives, farnesylemefuranones A-C (10-12); xylarinol C (13); and emericelloxide (14), along with four known compounds (dustanin, sorbicillin, aspergillodiol and xylarinol A), were isolated from the culture extracts of Emericella sp. IFM57991. Structures of 1-14 were elucidated on the basis of spectroscopic analysis and chemical evidence. Compounds 4-7 and 13 showed moderate antibacterial activities against Bacillus subtilis. |
| Volume | 69(2) |
| Pages | 89-96 |
| Published | 2016-2-1 |
| DOI | 10.1038/ja.2015.85 |
| PII | ja201585 |
| PMID | 26306816 |
| MeSH | Anti-Infective Agents / chemistry Anti-Infective Agents / isolation & purification Anti-Infective Agents / pharmacology* Bacillus subtilis / drug effects* Benzofurans / chemistry Benzofurans / isolation & purification Benzofurans / pharmacology* Culture Media / chemistry* Disk Diffusion Antimicrobial Tests Emericella / growth & development Emericella / metabolism* Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Phthalimides / chemistry Phthalimides / isolation & purification Phthalimides / pharmacology* |
| IF | 2.668 |
| Times Cited | 9 |
| WOS Category | PHARMACOLOGY & PHARMACY BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY IMMUNOLOGY |
| Resource | |
| Pathogenic microorganisms | IFM 57991 |