論文 - 詳細
| RRC ID | 401 |
|---|---|
| 著者 | Koshida S, Kishimoto Y, Ustumi H, Shimizu T, Furutani-Seiki M, Kondoh H, Takada S. |
| タイトル | Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. |
| ジャーナル | Dev Cell |
| Abstract |
Boundary formation and epithelialization are crucial processes in the morphological segmentation of vertebrate somites. By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes. Fibronectin proteins accumulate at somite boundaries in accordance with epithelialization of the somites. Both Fibronectin accumulation and the epithelialization are dependent on itga5, which is expressed in the most medial part of somites. Although somite boundaries are initially formed, but not maintained, in the anterior trunk of the mutant embryos deficient in either gene, their maintenance is defective at all axial levels of embryos deficient for both of these genes. Therefore, Integrinalpha5-directed assembly of Fibronectin appears critical for epithelialization and boundary maintenance of somites. Furthermore, with an additional deficiency in ephrin-B2a, the segmental defect in itga5 or fn mutant embryos is expanded posteriorly, indicating that both Integrin-Fibronectin and Eph-Ephrin systems function cooperatively in maintaining somite boundaries. |
| 巻・号 | 8(4) |
| ページ | 587-98 |
| 公開日 | 2005-4-1 |
| DOI | 10.1016/j.devcel.2005.03.006 |
| PII | S1534-5807(05)00090-0 |
| PMID | 15809040 |
| MeSH | Animals Body Patterning* Cell Polarity Ephrin-B2 / genetics Ephrin-B2 / metabolism Epithelium / embryology Fibronectins / genetics Fibronectins / metabolism* Gene Expression Regulation, Developmental In Situ Hybridization Integrin alpha5 / genetics Integrin alpha5 / metabolism* Morphogenesis Oligonucleotides, Antisense / genetics Oligonucleotides, Antisense / metabolism Somites / cytology* Somites / physiology* Zebrafish / anatomy & histology Zebrafish / embryology* Zebrafish / genetics Zebrafish / metabolism |
| IF | 10.092 |
| 引用数 | 136 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | kt293 kt451 kt664 kt259 kt443? |