RRC ID 4022
著者 Kim KC, Lai Z, Fan B, Chen Z.
タイトル Arabidopsis WRKY38 and WRKY62 transcription factors interact with histone deacetylase 19 in basal defense.
ジャーナル Plant Cell
Abstract Arabidopsis thaliana WRKY38 and WRKY62, encoding two structurally similar type III WRKY transcription factors, are induced in a Nonexpressor of PR Gene1 (NPR1)-dependent manner by salicylic acid (SA) or by virulent Pseudomonas syringae. Disease resistance and SA-regulated Pathogenesis-Related1 (PR1) gene expression are enhanced in the wrky38 and wrky62 single mutants and, to a greater extent, in the double mutants. Overexpression of WRKY38 or WRKY62 reduces disease resistance and PR1 expression. Thus, WRKY38 and WRKY62 function additively as negative regulators of plant basal defense. WRKY38 and WRKY62 interact with Histone Deacetylase 19 (HDA19). Expression of HDA19 is also induced by P. syringae, and the stability of its induced transcripts depends on SA and NPR1 in infected plants. Disruption of HDA19 leads to compromised resistance, whereas its overexpression results in enhanced resistance to P. syringae. Thus, HDA19 has a role opposite from those of WRKY38 and WRKY62 in basal resistance to the bacterial pathogen. Both WRKY38 and WRKY62 are transcriptional activators in plant cells, but their activation activities are abolished by overexpressed HDA19. Interaction of WRKY38 and WRKY62 with HDA19 may act to fine-tune plant basal defense responses.
巻・号 20(9)
ページ 2357-71
公開日 2008-9-1
DOI 10.1105/tpc.107.055566
PII tpc.107.055566
PMID 18776063
PMC PMC2570728
MeSH Arabidopsis / genetics Arabidopsis / metabolism* Arabidopsis / microbiology Arabidopsis Proteins / genetics Arabidopsis Proteins / metabolism* Arabidopsis Proteins / physiology Electrophoretic Mobility Shift Assay Gene Expression Regulation, Plant / drug effects Histone Deacetylases / genetics Histone Deacetylases / metabolism Histone Deacetylases / physiology Immunity, Innate / genetics Immunoprecipitation Models, Biological Plant Diseases / genetics Plant Diseases / microbiology Plant Proteins / genetics Plant Proteins / metabolism Plant Proteins / physiology Plants, Genetically Modified / genetics Plants, Genetically Modified / metabolism* Plants, Genetically Modified / microbiology Protein Binding Pseudomonas syringae / growth & development Reverse Transcriptase Polymerase Chain Reaction Salicylic Acid / pharmacology Transcription Factors / genetics Transcription Factors / metabolism Transcription Factors / physiology Two-Hybrid System Techniques
IF 9.618
引用数 281
WOS 分野 PLANT SCIENCES BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
シロイヌナズナ / 植物培養細胞・遺伝子 pst12851 pst12552