| RRC ID |
4065
|
| Author |
Liang H, Yao N, Song JT, Luo S, Lu H, Greenberg JT.
|
| Title |
Ceramides modulate programmed cell death in plants.
|
| Journal |
Genes Dev
|
| Abstract |
The balance between the bioactive sphingolipid ceramide and its phosphorylated derivative has been proposed to modulate the amount of programmed cell death (PCD) in eukaryotes. We characterized the first ceramide kinase (CERK) mutant in any organism. The Arabidopsis CERK mutant, called accelerated cell death 5, accumulates CERK substrates and shows enhanced disease symptoms during pathogen attack and apoptotic-like cell death dependent on defense signaling late in development. ACD5 protein shows high specificity for ceramides in vitro. Strikingly, C2 ceramide induces, whereas its phosphorylated derivative partially blocks, plant PCD, supporting a role for ceramide phosphorylation in modulating cell death in plants.
|
| Volume |
17(21)
|
| Pages |
2636-41
|
| Published |
2003-11-1
|
| DOI |
10.1101/gad.1140503
|
| PII |
1140503
|
| PMID |
14563678
|
| PMC |
PMC280613
|
| MeSH |
Apoptosis / physiology*
Arabidopsis / metabolism*
Ceramides / metabolism*
|
| IF |
9.527
|
| Times Cited |
237
|
|
WOS Category
|
GENETICS & HEREDITY
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| Resource |
| Arabidopsis / Cultured plant cells, genes |
pda00534 |
