| RRC ID |
4068
|
| Author |
Yanase S, Onodera A, Tedesco P, Johnson TE, Ishii N.
|
| Title |
SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation.
|
| Journal |
J Gerontol A Biol Sci Med Sci
|
| Abstract |
Superoxide dismutase (SOD) is an enzyme that catalytically removes the superoxide radical (*O2-) and protects organisms from oxidative damage during normal aging. We demonstrate that not only the cytosolic *O2- level but also the mitochondrial *O2- level increases in the deletion mutants of sod-1 gene encoding Cu/Zn SOD in Caenorhabditis elegans (C. elegans). Interestingly, this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria. We also found functional compensation by other SODs, especially the sod-5 gene, which was induced several fold in the mutants. Therefore, the possibility exists that the compensative expression of sod-5 gene in the sod-1 deficit is associated with the insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, which regulates longevity and stress resistance of C. elegans because the sod-5 gene may be a target of the pathway.
|
| Volume |
64(5)
|
| Pages |
530-9
|
| Published |
2009-5-1
|
| DOI |
10.1093/gerona/glp020
|
| PII |
glp020
|
| PMID |
19282511
|
| MeSH |
Animals
Caenorhabditis elegans
Gene Expression Regulation, Enzymologic*
Longevity / genetics*
Mitochondria / enzymology*
Reactive Oxygen Species / metabolism*
Superoxide Dismutase / genetics*
Superoxide Dismutase-1
|
| IF |
5.236
|
| Times Cited |
46
|
|
WOS Category
|
GERONTOLOGY
GERIATRICS & GERONTOLOGY
|
| Resource |
| C.elegans |
tm776
tm783 |
