Reference - Detail
| RRC ID | 4068 |
|---|---|
| Author | Yanase S, Onodera A, Tedesco P, Johnson TE, Ishii N. |
| Title | SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation. |
| Journal | J Gerontol A Biol Sci Med Sci |
| Abstract |
Superoxide dismutase (SOD) is an enzyme that catalytically removes the superoxide radical (*O2-) and protects organisms from oxidative damage during normal aging. We demonstrate that not only the cytosolic *O2- level but also the mitochondrial *O2- level increases in the deletion mutants of sod-1 gene encoding Cu/Zn SOD in Caenorhabditis elegans (C. elegans). Interestingly, this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria. We also found functional compensation by other SODs, especially the sod-5 gene, which was induced several fold in the mutants. Therefore, the possibility exists that the compensative expression of sod-5 gene in the sod-1 deficit is associated with the insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, which regulates longevity and stress resistance of C. elegans because the sod-5 gene may be a target of the pathway. |
| Volume | 64(5) |
| Pages | 530-9 |
| Published | 2009-5-1 |
| DOI | 10.1093/gerona/glp020 |
| PII | glp020 |
| PMID | 19282511 |
| MeSH | Animals Caenorhabditis elegans Gene Expression Regulation, Enzymologic* Longevity / genetics* Mitochondria / enzymology* Reactive Oxygen Species / metabolism* Superoxide Dismutase / genetics* Superoxide Dismutase-1 |
| IF | 5.236 |
| Times Cited | 46 |
| WOS Category | GERONTOLOGY GERIATRICS & GERONTOLOGY |
| Altmetric score |
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm776 tm783 |