論文 - 詳細
| RRC ID | 40930 |
|---|---|
| 著者 | Aiba Y, Nakano Y, Koga Y, Takahashi K, Komatsu Y. |
| タイトル | A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice. |
| ジャーナル | Microbiologyopen |
| Abstract |
A novel strain of Lactobacillus johnsonii No. 1088 was isolated from the gastric juice of a healthy Japanese male volunteer, and characterized for its effectiveness in the stomach environment. Lactobacillus johnsonii No. 1088 was found to have the strongest acid resistance among several lactobacilli examined (>10% of cells survived at pH 1.0 after 2 h), and such a high acid resistance property was a specific characteristic of this strain of L. johnsonii. When cultured with various virulent bacteria, L. johnsonii No. 1088 inhibited the growth of Helicobacter pylori, Escherichia coli O-157, Salmonella Typhimurium, and Clostridium difficile, in which case its effectiveness was more potent than that of a type strain of L. johnsonii, JCM2012. In addition to its effect in vitro, L. johnsonii No. 1088 inhibited the growth of H. pylori in human intestinal microbiota-associated mice in both its live and lyophilized forms. Moreover, L. johnsonii No. 1088 suppressed gastric acid secretion in mice via decreasing the number of gastrin-positive cells in the stomach. These results taken together suggest that L. johnsonii No. 1088 is a unique lactobacillus having properties beneficial for supporting H. pylori eradication by triple therapy including the use of a proton pump inhibitor (PPI) and also for prophylaxis of gastroesophageal reflux disease possibly caused after H. pylori eradication as a side effect of PPI. |
| 巻・号 | 4(3) |
| ページ | 465-74 |
| 公開日 | 2015-6-1 |
| DOI | 10.1002/mbo3.252 |
| PMID | 25771812 |
| PMC | PMC4475388 |
| MeSH | Animals Antibiosis* Disease Models, Animal Gastric Acid / metabolism* Gastrins / blood Gastrins / metabolism* Gastrointestinal Microbiome Helicobacter Infections / metabolism Helicobacter Infections / microbiology Helicobacter pylori / physiology* Humans Lactobacillus / isolation & purification Lactobacillus / physiology* Mice Proton Pump Inhibitors / pharmacology |
| IF | 3.142 |
| 引用数 | 17 |
| WOS 分野 | MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 2012 JCM 1131 JCM 1296 |