RRC ID 40930
著者 Aiba Y, Nakano Y, Koga Y, Takahashi K, Komatsu Y.
タイトル A highly acid-resistant novel strain of Lactobacillus johnsonii No. 1088 has antibacterial activity, including that against Helicobacter pylori, and inhibits gastrin-mediated acid production in mice.
ジャーナル Microbiologyopen
Abstract A novel strain of Lactobacillus johnsonii No. 1088 was isolated from the gastric juice of a healthy Japanese male volunteer, and characterized for its effectiveness in the stomach environment. Lactobacillus johnsonii No. 1088 was found to have the strongest acid resistance among several lactobacilli examined (>10% of cells survived at pH 1.0 after 2 h), and such a high acid resistance property was a specific characteristic of this strain of L. johnsonii. When cultured with various virulent bacteria, L. johnsonii No. 1088 inhibited the growth of Helicobacter pylori, Escherichia coli O-157, Salmonella Typhimurium, and Clostridium difficile, in which case its effectiveness was more potent than that of a type strain of L. johnsonii, JCM2012. In addition to its effect in vitro, L. johnsonii No. 1088 inhibited the growth of H. pylori in human intestinal microbiota-associated mice in both its live and lyophilized forms. Moreover, L. johnsonii No. 1088 suppressed gastric acid secretion in mice via decreasing the number of gastrin-positive cells in the stomach. These results taken together suggest that L. johnsonii No. 1088 is a unique lactobacillus having properties beneficial for supporting H. pylori eradication by triple therapy including the use of a proton pump inhibitor (PPI) and also for prophylaxis of gastroesophageal reflux disease possibly caused after H. pylori eradication as a side effect of PPI.
巻・号 4(3)
ページ 465-74
公開日 2015-6-1
DOI 10.1002/mbo3.252
PMID 25771812
PMC PMC4475388
MeSH Animals Antibiosis* Disease Models, Animal Gastric Acid / metabolism* Gastrins / blood Gastrins / metabolism* Gastrointestinal Microbiome Helicobacter Infections / metabolism Helicobacter Infections / microbiology Helicobacter pylori / physiology* Humans Lactobacillus / isolation & purification Lactobacillus / physiology* Mice Proton Pump Inhibitors / pharmacology
IF 3.142
引用数 17
WOS 分野 MICROBIOLOGY
リソース情報
一般微生物 JCM 2012 JCM 1131 JCM 1296