論文 - 詳細
| RRC ID | 41 |
|---|---|
| 著者 | Hamada S, Nakajima K, Serikawa T, Hayashi M. |
| タイトル | The effect of aging on the results of the rat micronucleus assay. |
| ジャーナル | Mutagenesis |
| Abstract |
We conducted the micronucleus assay in 3-, 5-, 7-, 9-, 11- and 13-week-old male rats to determine whether the results varied with age. We administered cyclophosphamide orally at 0 (vehicle), 5, 10 or 20 mg/kg, twice, 24 h apart, to five rats per dosage group and collected bone marrow and peripheral blood 24 h after the second treatment. We observed an age-related decrease in micronucleus-inducing activity in both polychromatic erythrocytes (bone marrow) and reticulocytes (peripheral blood), which we attributed to an age-related decrease in hematopoiesis. In spite of the age-related decrease in sensitivity to the model chemical studied here, all age groups tested showed positive responses. We concluded that the rat is suitable for the micronucleus assay regardless of age. |
| 巻・号 | 18(3) |
| ページ | 273-5 |
| 公開日 | 2003-5-1 |
| DOI | 10.1093/mutage/18.3.273 |
| PMID | 12714693 |
| MeSH | Age Factors Animals Biological Assay* Bone Marrow Cells / metabolism Cyclophosphamide / pharmacology Dose-Response Relationship, Drug Leukocytes / metabolism Male Micronuclei, Chromosome-Defective / drug effects Micronuclei, Chromosome-Defective / metabolism* Mutagens / pharmacology Rats |
| IF | 3.379 |
| 引用数 | 18 |
| WOS 分野 | TOXICOLOGY GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ラット | |