論文 - 詳細
| RRC ID | 4113 |
|---|---|
| 著者 | Tabor R, Yaksi E, Friedrich RW. |
| タイトル | Multiple functions of GABA A and GABA B receptors during pattern processing in the zebrafish olfactory bulb. |
| ジャーナル | Eur J Neurosci |
| Abstract |
gamma-Aminobutyric acid (GABA)ergic synapses are thought to play pivotal roles in the processing of activity patterns in the olfactory bulb (OB), but their functions have been difficult to study during odor responses in the intact system. We pharmacologically manipulated GABA(A) and GABA(B) receptors in the OB of zebrafish and analysed the effects on odor responses of the output neurons, the mitral cells (MCs), by electrophysiological recordings and temporally deconvolved two-photon Ca2+ imaging. The blockade of GABA(B) receptors enhanced presynaptic Ca2+ influx into afferent axon terminals, and changed the amplitude and time course of a subset of MC responses, indicating that GABA(B) receptors have a modulatory influence on OB output activity. The blockade of GABA(A) receptors induced epileptiform firing, enhanced excitatory responses and abolished fast oscillations in the local field potential. Moreover, the topological reorganization and decorrelation of MC activity patterns during the initial phase of the response was perturbed. These results indicate that GABA(A) receptor-containing circuits participate in the balance of excitation and inhibition, the regulation of total OB output activity, the synchronization of odor-dependent neuronal ensembles, and the reorganization of odor-encoding activity patterns. GABA(A) and GABA(B) receptors are therefore differentially involved in multiple functions of neuronal circuits in the OB. |
| 巻・号 | 28(1) |
| ページ | 117-27 |
| 公開日 | 2008-7-1 |
| DOI | 10.1111/j.1460-9568.2008.06316.x |
| PII | EJN6316 |
| PMID | 18616562 |
| MeSH | Animals Baclofen / metabolism Calcium / metabolism Food GABA Agonists / metabolism GABA Antagonists / metabolism Neural Pathways / anatomy & histology Neural Pathways / physiology Neurons / cytology Neurons / metabolism Odorants Olfactory Bulb / cytology Olfactory Bulb / metabolism* Organophosphorus Compounds / metabolism Patch-Clamp Techniques Pyridazines / metabolism Receptors, GABA-A / genetics Receptors, GABA-A / metabolism* Receptors, GABA-B / genetics Receptors, GABA-B / metabolism* Smell / physiology* Zebrafish / anatomy & histology Zebrafish / physiology |
| IF | 3.115 |
| 引用数 | 27 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg[HuC:Inverse-pericam] |