論文 - 詳細
| RRC ID | 41337 |
|---|---|
| 著者 | Leung WK, To KF, Ng YP, Lee TL, Lau JY, Chan FK, Ng EK, Chung SC, Sung JJ. |
| タイトル | Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer. |
| ジャーナル | Br J Cancer |
| Abstract |
Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expression was seen in 19 (48.7%) cases. These tumours had more lymph-node metastasis (P = 0.048) and tended to have a poorer survival (P = 0.07). Missense mutations of p53 were detected in 20 (51.3%) patients and had a significantly stronger COX-2 expression than tumours without p53 mutation (P = 0.016). Our results suggest a link between p53 mutation and COX-2 overexpression in gastric cancer. |
| 巻・号 | 84(3) |
| ページ | 335-9 |
| 公開日 | 2001-2-2 |
| DOI | 10.1054/bjoc.2000.1607 |
| PII | S0007092000916070 |
| PMID | 11161397 |
| PMC | PMC2363738 |
| MeSH | Adult Aged Aged, 80 and over Cyclooxygenase 2 DNA / chemistry DNA / genetics DNA Mutational Analysis Female Humans Immunohistochemistry Isoenzymes / biosynthesis* Male Membrane Proteins Middle Aged Mutation, Missense Polymorphism, Single-Stranded Conformational Prostaglandin-Endoperoxide Synthases / biosynthesis* Stomach Neoplasms / enzymology Stomach Neoplasms / genetics Stomach Neoplasms / pathology* Survival Analysis Tumor Suppressor Protein p53 / genetics* |
| IF | 5.791 |
| 引用数 | 97 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | MKN45(RCB1001) |