論文 - 詳細
| RRC ID | 41353 |
|---|---|
| 著者 | Ueno Y, Harada T, Iseki H, Ohshima T, Sugiyama F, Yagami K. |
| タイトル | Propagation of rat parvovirus in thymic lymphoma cell line C58(NT)d and subsequent appearance of a resistant cell clone after lytic infection. |
| ジャーナル | J Virol |
| Abstract |
Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphocytotropic infection. We found that RPV was propagated in rat thymic lymphoma cell line C58(NT)D and induced apoptosis. Interestingly, a resistant subclone, C58(NT)D/R, from surviving cells after lytic infection had differentiated phenotypic modifications, such as increased cell adherence, resistance to apoptosis, and suppressed tumorigenicity. |
| 巻・号 | 75(8) |
| ページ | 3965-70 |
| 公開日 | 2001-4-1 |
| DOI | 10.1128/JVI.75.8.3965-3970.2001 |
| PMID | 11264385 |
| PMC | PMC114887 |
| MeSH | Animals Apoptosis / radiation effects Cell Adhesion Cell Differentiation Cell Line Cell Transformation, Neoplastic Clone Cells / pathology Clone Cells / radiation effects Clone Cells / transplantation Clone Cells / virology Lymphoma / pathology Lymphoma / virology* Mice Mice, Nude Neoplasm Transplantation Parvovirus / pathogenicity Parvovirus / physiology* Phenotype Rats Serial Passage Thymus Gland / pathology Thymus Gland / radiation effects Thymus Gland / transplantation Thymus Gland / virology* Time Factors Tumor Cells, Cultured Virus Replication* |
| IF | 4.501 |
| 引用数 | 7 |
| WOS 分野 | VIROLOGY |
| リソース情報 | |
| ヒト・動物細胞 | BHK-21 |