論文 - 詳細
| RRC ID | 41428 |
|---|---|
| 著者 | Min BS, Gao JJ, Nakamura N, Kim YH, Hattori M. |
| タイトル | Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. japonicum. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
A new pyrrolophenanthridone alkaloid, criasiaticidine A (1), was isolated from the bulbs of Crinum asiaticum var. japonicum, together with pratorimine (2), lycorine (3) and 4'-hydroxy-7-methoxyflavan (4). The structure of the new alkaloid was determined to be 4,5-etheno-9,10-dihydroxy-6-phenanthridone by spectroscopic means. The cytotoxicity of the isolated compounds 1-4 was evaluated in vitro against Meth-A (mouse sarcoma) and Lewis lung carcinoma (mouse lung carcinoma) tumor cell lines. Furthermore, 3 was examined for in vivo antitumor activity with LLC tumor cells. |
| 巻・号 | 49(9) |
| ページ | 1217-9 |
| 公開日 | 2001-9-1 |
| DOI | 10.1248/cpb.49.1217 |
| PMID | 11558618 |
| MeSH | Alkaloids / chemistry* Alkaloids / pharmacology* Animals Antineoplastic Agents, Phytogenic / chemistry* Antineoplastic Agents, Phytogenic / pharmacology* Chromatography, Liquid Female Indicators and Reagents Japan Magnetic Resonance Spectroscopy Mass Spectrometry Mice Neoplasm Transplantation Neoplasms, Experimental / drug therapy Phenanthrenes / chemistry Phenanthrenes / pharmacology* Plant Roots / chemistry Plants, Medicinal / chemistry* Spectrophotometry, Ultraviolet Tumor Cells, Cultured |
| IF | 1.416 |
| 引用数 | 35 |
| WOS 分野 | CHEMISTRY, MULTIDISCIPLINARY PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | Meth-A LLC |