| RRC ID |
41458
|
| Author |
Takanami I, Takeuchi K, Watanabe H, Yanagawa T, Takagishi K.
|
| Title |
Autocrine motility factor receptor gene expression and cell motility in lung cancer cell lines.
|
| Journal |
Oncol Rep
|
| Abstract |
The cell motility of tumor cells is an integral component of tumor invasion and metastasis. Autocrine motility factor (AMF) stimulates cell motility via a receptor (R)-mediated signal pathway. We studied the correlation between level of AMF-R gene expression by reverse transcription-polymerase chain reaction and cell motility by phagokinetic track assay with or without AMF in lung cancer cell lines. Lung cancer cell lines with higher AMF-R gene expression tended to have greater cell motility than those with lower AMF-R gene expression with or without AMF. Most of lung cancer cell lines showed significantly increased motility with the stimulation of AMF. We conclude that the presence of higher AMF-R gene expression and tumor cell motility via receptor in response to the stimulation of AMF could be an important aspect in the invasion and metastasis of lung cancer cell lines.
|
| Volume |
9(1)
|
| Pages |
125-8
|
| Published |
2002-1-1
|
| PMID |
11748469
|
| MeSH |
Carcinoma, Non-Small-Cell Lung / genetics*
Carcinoma, Non-Small-Cell Lung / metabolism
Cell Movement
DNA Primers / chemistry
Gene Expression
Glucose-6-Phosphate Isomerase / pharmacology
HeLa Cells
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism
Receptors, Autocrine Motility Factor
Receptors, Cytokine / genetics*
Receptors, Cytokine / metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured / metabolism
Ubiquitin-Protein Ligases
|
| IF |
3.417
|
| Times Cited |
3
|
|
WOS Category
|
ONCOLOGY
|
| Resource |
| Human and Animal Cells |
|
