論文 - 詳細
| RRC ID | 41467 |
|---|---|
| 著者 | Su GH, Song JJ, Repasky EA, Schutte M, Kern SE. |
| タイトル | Mutation rate of MAP2K4/MKK4 in breast carcinoma. |
| ジャーナル | Hum Mutat |
| Abstract |
The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The relevant inputs include Ras proteins as well as exposure of cells to ultraviolet light, tumor-necrosis factor, and other stress-related inputs. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 (MKK4, SEK, JNKK1) is a centrally-placed mediator of the SAPK pathways. MAP2K4 mutations or homozygous deletions are reported in about 5% of a wide variety of tumor types. The exception is breast cancer, where genetic inactivation in 3 of 22 (15%) cell lines had suggested that the mutational involvement of MAP2K4 might be accentuated in this tumor type. This finding might have represented an important difference, or solely a chance numerical variation. To address this question, we studied an independent panel of 20 breast cancer cell lines and xenografts for MAP2K4 alterations. We found a splice acceptor mutation accompanied by loss of the other allele in the cell line MPE600. This was the sole alteration in this panel (5% of tumors). These data seem to re-establish a rather consistent rate of genetic inactivation of MAP2K4 among most tumor types, including breast cancer. The genetic evaluation of other mediators of the SAPK pathways might offer insight into a promising, but as yet poorly defined, tumor-suppressive system. |
| 巻・号 | 19(1) |
| ページ | 81 |
| 公開日 | 2002-1-1 |
| DOI | 10.1002/humu.9002 |
| PII | 10.1002/humu.9002 |
| PMID | 11754110 |
| MeSH | Animals Breast Neoplasms / enzymology* Breast Neoplasms / genetics* Female Humans Loss of Heterozygosity / genetics MAP Kinase Kinase 4* Mammary Neoplasms, Experimental / enzymology Mammary Neoplasms, Experimental / genetics Mice Mice, SCID Mitogen-Activated Protein Kinase Kinases / genetics* Mutagenesis / genetics* Mutation / genetics Neoplasm Transplantation RNA Splice Sites / genetics Transplantation, Heterologous Tumor Cells, Cultured |
| IF | 4.124 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | OCUB-F(RCB0882) OCUB-M(RCB0881) |