| RRC ID |
41469
|
| 著者 |
Terano A, Sakata-Horie K, Shimada T, Hiraishi H, Yoshiura K, Yoneda M, Takahashi M, Fujimori T.
|
| タイトル |
The role of cellular migration in the repair process of gastric epithelial cells.
|
| ジャーナル |
Life Sci
|
| Abstract |
The epithelial cells of stomach are continuously exposed to various toxic agents that may cause mucosal injury. The epithelial lining is rapidly replaced by cells that migrate from the proliferative zone of the gastric gland, to maintain the integrity of the gastric mucosa. Thus, cell migration is an essential part of the early process of gastric mucosal repair. After various forms of gastric injury, mucosal integrity is reestablished by the rapid migration of epithelial cells. However, the cellular mechanisms of the restitution remain unclear to date. In this report, we will review the role of cellular migration in the repair process of gastric epithelial cells in culture. It has been reported that hepatocyte growth factor (HGF) has the potency of acceleration of cellular repair process. In this review, we also report that HGF plays a leading role in the mucosal repair after damage by using a novel cell culture model.
|
| 巻・号 |
69(25-26)
|
| ページ |
3083-9
|
| 公開日 |
2001-11-9
|
| DOI |
10.1016/s0024-3205(01)01414-x
|
| PII |
S0024-3205(01)01414-X
|
| PMID |
11758833
|
| MeSH |
Animals
Blotting, Northern
Cell Movement / drug effects
Cell Movement / physiology*
Cells, Cultured
Cyclooxygenase Inhibitors / pharmacology
Dose-Response Relationship, Drug
Epithelial Cells / cytology
Epithelial Cells / drug effects
Epithelial Cells / physiology
Gastric Mucosa / cytology
Gastric Mucosa / drug effects
Gastric Mucosa / physiology*
Hepatocyte Growth Factor / pharmacology
Hepatocyte Growth Factor / physiology*
Nitrobenzenes / pharmacology
Rabbits
Rats
Sulfonamides / pharmacology
Time Factors
Wound Healing / drug effects
Wound Healing / physiology*
|
| IF |
3.647
|
| 引用数 |
12
|
|
WOS 分野
|
MEDICINE, RESEARCH & EXPERIMENTAL
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ヒト・動物細胞 |
RGM1(RCB0876) |
