論文 - 詳細
| RRC ID | 41483 |
|---|---|
| 著者 | Masuoka M, Yoshimuta T, Hamada M, Okamoto M, Fumimori T, Honda J, Oizumi K, Itoh K. |
| タイトル | Identification of the HLA-A24 peptide epitope within cytomegalovirus protein pp65 recognized by CMV-specific cytotoxic T lymphocytes. |
| ジャーナル | Viral Immunol |
| Abstract |
Among cytomegalovirus (CMV) tegument proteins, phosphoprotein 65 (pp65) has been identified as the important target antigen of the cytotoxic T lymphocyte (CTL) response against the virus. We synthesized seven CMV-pp65-derived peptides carrying an HLA-A24-binding motif, and investigated the ability of these peptides to induce CMV-specific CTL. We identified one nonamer peptide (pp65113-121; VYALPLKML) able to bind HLA-A24 and induce CTL responses in vitro in peripheral blood mononuclear cells (PBMC) from CMV-seropositive individuals. The peptide-specific CTLs generated were capable of recognizing pp65 expressed on CMV-infected fibroblasts as well as pp65113-121 peptide bound to the surface of C1R-A*2402 cells in an HLA-A24-restricted manner. The pp65113-121 peptide thus might be considered a synthetic peptide vaccine in HLA-A24-positive individuals. |
| 巻・号 | 14(4) |
| ページ | 369-77 |
| 公開日 | 2001-1-1 |
| DOI | 10.1089/08828240152716619 |
| PMID | 11792066 |
| MeSH | Antigens, Viral / immunology Cells, Cultured Cytomegalovirus / immunology* Epitopes, T-Lymphocyte / immunology* HLA-A Antigens / analysis* HLA-A Antigens / immunology HLA-A24 Antigen Humans Peptides / chemical synthesis Peptides / immunology Phosphoproteins / chemical synthesis Phosphoproteins / immunology* T-Lymphocytes, Cytotoxic / immunology* Viral Matrix Proteins / chemical synthesis Viral Matrix Proteins / immunology* |
| IF | 1.716 |
| 引用数 | 26 |
| WOS 分野 | IMMUNOLOGY VIROLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MRC-5(RCB0211) |