論文 - 詳細
| RRC ID | 4149 |
|---|---|
| 著者 | Cooper KL, Leisenring WM, Moens CB. |
| タイトル | Autonomous and nonautonomous functions for Hox/Pbx in branchiomotor neuron development. |
| ジャーナル | Dev Biol |
| Abstract |
The vertebrate branchiomotor neurons are organized in a pattern that corresponds with the segments, or rhombomeres, of the developing hindbrain and have identities and behaviors associated with their position along the anterior/posterior axis. These neurons undergo characteristic migrations in the hindbrain and project from stereotyped exit points. We show that lazarus/pbx4, which encodes an essential Hox DNA-binding partner in zebrafish, is required for facial (VIIth cranial nerve) motor neuron migration and for axon pathfinding of trigeminal (Vth cranial nerve) motor axons. We show that lzr/pbx4 is required for Hox paralog group 1 and 2 function, suggesting that Pbx interacts with these proteins. Consistent with this, lzr/pbx4 interacts genetically with hoxb1a to control facial motor neuron migration. Using genetic mosaic analysis, we show that lzr/pbx4 and hoxb1a are primarily required cell-autonomously within the facial motor neurons; however, analysis of a subtle non-cell-autonomous effect indicates that facial motor neuron migration is promoted by interactions amongst the migrating neurons. At the same time, lzr/pbx4 is required non-cell-autonomously to control the pathfinding of trigeminal motor axons. Thus, Pbx/Hox can function both cell-autonomously and non-cell-autonomously to direct different aspects of hindbrain motor neuron behavior. |
| 巻・号 | 253(2) |
| ページ | 200-13 |
| 公開日 | 2003-1-15 |
| DOI | 10.1016/s0012-1606(02)00018-0 |
| PII | S0012-1606(02)00018-0 |
| PMID | 12645925 |
| MeSH | Animals Animals, Genetically Modified Cell Movement / genetics DNA-Binding Proteins* Facial Nerve / embryology Gene Targeting Genes, Homeobox* Glycosyltransferases / genetics Green Fluorescent Proteins Homeodomain Proteins / genetics Luminescent Proteins / genetics Mosaicism Motor Neurons / cytology* Neural Pathways / embryology Rhombencephalon / embryology Trigeminal Nerve / embryology Zebrafish / genetics* Zebrafish / growth & development* Zebrafish Proteins / genetics |
| IF | 2.896 |
| 引用数 | 47 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ゼブラフィッシュ | rw0 (Tg(CM-isl1:GFP)) |